ArticleProceedings of the National Academy of Sciences of the United States of America2013
Dendritic growth gated by a steroid hormone receptor underlies increases in activity in the developing Drosophila locomotor system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Characterizing stage-dependent neuromotor patterns inFrontiers in neuroscience · 2025Article
- Drosophila postembryonic nervous system development: a model for the endocrine control of development.Genetics · 2023Review
- Article
- Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases.Frontiers in cellular neuroscience · 2022Article
- Article
- Reactive Oxygen Species Mediate Activity-Regulated Dendritic Plasticity Through NADPH Oxidase and Aquaporin Regulation.Frontiers in cellular neuroscience · 2021Article
- Structural and Functional Plasticity in the Regenerating Olfactory System of the Migratory Locust.Frontiers in physiology · 2020Review
- Maintenance of cell type-specific connectivity and circuit function requires Tao kinase.Nature communications · 2019Article
- Article
- Regulation of neuronal development and function by ROS.FEBS letters · 2018Review
- Conserved neural circuit structure acrosseLife · 2017Article
- Regeneration of synapses in the olfactory pathway of locusts after antennal deafferentation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Transcriptional Reorganization ofFrontiers in molecular neuroscience · 2017Article
- Neural Circuits Underlying Fly Larval Locomotion.Current pharmaceutical design · 2017Review
- Article
- Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron.PLoS computational biology · 2015Article
- Development of connectivity in a motoneuronal network in Drosophila larvae.Current biology : CB · 2015Article
- Steroid Receptor Isoform Expression in Drosophila Nociceptor Neurons Is Required for Normal Dendritic Arbor and Sensitivity.PloS one · 2015Article
- Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models.Frontiers in cellular neuroscience · 2014Review
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Authors and funding
4 authors.
Funding
Abstract
As animals grow, their nervous systems also increase in size. How growth in the central nervous system is regulated and its functional consequences are incompletely understood. We explored these questions, using the larval Drosophila locomotor system as a model. In the periphery, at neuromuscular junctions, motoneurons are known to enlarge their presynaptic axon terminals in size and strength, thereby compensating for reductions in muscle excitability that are associated with increases in muscle size. Here, we studied how motoneurons change in the central nervous system during periods of animal growth. We find that within the central nervous system motoneurons also enlarge their postsynaptic dendritic arbors, by the net addition of branches, and that these scale with overall animal size. This dendritic growth is gated on a cell-by-cell basis by a specific isoform of the steroid hormone receptor ecdysone receptor-B2, for which functions have thus far remained elusive. The dendritic growth is accompanied by synaptic strengthening and results in increased neuronal activity. Electrical properties of these neurons, however, are independent of ecdysone receptor-B2 regulation. We propose that these structural dendritic changes in the central nervous system, which regulate neuronal activity, constitute an additional part of the adaptive response of the locomotor system to increases in body and muscle size as the animal grows.
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