ArticleProceedings of the National Academy of Sciences of the United States of America2013
Early evolution of the T-box transcription factor family.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 86 citations in OpenAlex.
- Article
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- The evolutionary foundations of transcriptional regulation in animals.Nature reviews. Genetics · 2025Review
- Deep homology of aScience advances · 2025Article
- A High-Throughput Drug Repurposing Strategy to Treat TBX2 and/or TBX3 Dependent Cancers.Cancer medicine · 2024Article
- New insights into mesoderm and endoderm development, and the nature of the onychophoran blastopore.Frontiers in zoology · 2024Article
- Conserved enhancers control notochord expression of vertebrate Brachyury.Nature communications · 2023Article
- The evolutionary history of Brachyury genes in Hydrozoa involves duplications, divergence, and neofunctionalization.Scientific reports · 2023Article
- An ancestral Wnt-Brachyury feedback loop in axial patterning and recruitment of mesoderm-determining target genes.Nature ecology & evolution · 2022Article
- Shared cis-regulatory modules control expression of the tandem paralogs midline and H15 in the follicular epithelium.Development (Cambridge, England) · 2022Article
- A mosaic of conserved and novel modes of gene expression and morphogenesis in mesoderm and muscle formation of a larval bivalve.Organisms, diversity & evolution · 2022Article
- Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops.Frontiers in cell and developmental biology · 2022Article
- The Non-continuum Nature of Eukaryotic Transcriptional Regulation.Advances in experimental medicine and biology · 2022Article
- Review
- The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition.Open biology · 2021Review
- Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.Cell reports. Medicine · 2021Article
- Intracellular and Intercellular Gene Regulatory Network Inference From Time-Course Individual RNA-Seq.Frontiers in bioinformatics · 2021Article
- The genetic factors of bilaterian evolution.eLife · 2020Article
- Insights into the origin of metazoan multicellularity from predatory unicellular relatives of animals.BMC biology · 2020Article
- T-Box Transcription Factor 22 Is an Immune Microenvironment-Related Biomarker Associated With theFrontiers in cell and developmental biology · 2020Article
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Authors and funding
11 authors at 7 institutions in 4 countries.
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Abstract
Developmental transcription factors are key players in animal multicellularity, being members of the T-box family that are among the most important. Until recently, T-box transcription factors were thought to be exclusively present in metazoans. Here, we report the presence of T-box genes in several nonmetazoan lineages, including ichthyosporeans, filastereans, and fungi. Our data confirm that Brachyury is the most ancient member of the T-box family and establish that the T-box family diversified at the onset of Metazoa. Moreover, we demonstrate functional conservation of a homolog of Brachyury of the protist Capsaspora owczarzaki in Xenopus laevis. By comparing the molecular phenotype of C. owczarzaki Brachyury with that of homologs of early branching metazoans, we define a clear difference between unicellular holozoan and metazoan Brachyury homologs, suggesting that the specificity of Brachyury emerged at the origin of Metazoa. Experimental determination of the binding preferences of the C. owczarzaki Brachyury results in a similar motif to that of metazoan Brachyury and other T-box classes. This finding suggests that functional specificity between different T-box classes is likely achieved by interaction with alternative cofactors, as opposed to differences in binding specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.