Evidence map›Paper›PMID 24043698›Full record

ArticleThe Journal of cell biology2013

pHocal adhesion kinase regulation is on a FERM foundation.

Christine Lawson, David D Schlaepfer

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution.

Christine LawsonDepartment of Reproductive Medicine, Moores UCSD Cancer Center, La Jolla, CA 92093.
David D Schlaepfer
Moores Cancer Center

Funding

Signaling Connections Controlling Cell Motility and InvasionR01CA180769 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHLAEPFER, DAVID D · 2013 to 2017
$1.9M
NCI NIH HHS CA103210NCI NIH HHS CA180769NCI NIH HHS R01 CA180769
6 · The paper itself

Abstract

Increases in intracellular pH (pHi) occur upon integrin receptor binding to matrix proteins and in tumor cells. In this issue, Choi et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201308034) show that pHi increase activates FAK by causing deprotonation of histidine 58 in its FERM (band 4.1, ezrin, radixin, moesin) homology domain, which exposes a region important for FAK autophosphorylation. This model of FAK activation could contribute to motility of tumor cells by promoting focal adhesion turnover.

Indexed as

AnimalsCation Transport ProteinsEmbryo, MammalianFemaleFibroblastsFocal Adhesion Kinase 1Focal AdhesionsHistidineHumansSodium-Hydrogen Exchanger 1Sodium-Hydrogen ExchangersCation Transport ProteinsFocal Adhesion Kinase 1HistidinePtk2 protein, mouseSlc9a1 protein, mouseSodium-Hydrogen Exchanger 1Sodium-Hydrogen Exchangers

Identifiers

PMID24043698
PMCPMC3776349
OpenAlexW2092411539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.