Evidence map›Paper›PMID 24043661›Full record

SynthesisCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2013

Efficacy and safety of cognitive enhancers for patients with mild cognitive impairment: a systematic review and meta-analysis.

Andrea C Tricco, Charlene Soobiah, Shirra Berliner, Joanne M Ho, Carmen H Ng, Huda M Ashoor, Maggie H Chen, Brenda Hemmelgarn, Sharon E Straus

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06644690 (The Effect of a Creative Dance-Supported CO-OP Approach on Executive Functions, Attention, Memory, and Dual-Task Performance in Older Adults With Mild Cognitive Impairment), which is not on this map. Cited by 103 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 19 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06644690 nacompletednot on this mapstarted 2024, after this paper: background citation

The Effect of a Creative Dance-Supported CO-OP Approach on Executive Functions, Attention, Memory, and Dual-Task Performance in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial

TypeinterventionalSponsorÇankırı Karatekin UniversityRan2024 to 2025Enrolled26ConditionsMild Cognitive Impairment (MCI)ArmsCO-OP with Creative Dance, CO-OP Only
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 19 syntheses or guidelines pooled it, 205 citations in OpenAlex.

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  5. Cognition enhancing effect of rosemary (Rosmarinus officinalis L.) in lab animal studies: a systematic review and meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
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  16. Recommendations on screening for cognitive impairment in older adults.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016
    Guideline
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  20. Trial

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Andrea C Tricco
Charlene Soobiah
Shirra Berliner
Joanne M Ho
Carmen H Ng
Huda M Ashoor
Maggie H Chen
Brenda Hemmelgarn
Sharon E Straus
St. Michael's Hospital · CA

Funding

Canadian Institutes of Health Research 257990
6 · The paper itself

Abstract

backgroundCognitive enhancers, including cholinesterase inhibitors and memantine, are used to treat dementia, but their effectiveness for mild cognitive impairment is unclear. We conducted a systematic review to examine the efficacy and safety of cognitive enhancers for mild cognitive impairment.

methodsOur eligibility criteria were studies of the effects of donepezil, rivastigmine, galantamine or memantine on mild cognitive impairment reporting cognition, function, behaviour, global status, and mortality or harms. We identified relevant material by searching electronic databases (e.g., MEDLINE, Embase), the references of included studies, trial registries and conference proceedings, and by contacting experts. Two reviewers independently screened the results of the literature search, abstracted data and appraised risk of bias using the Cochrane risk-of-bias tool.

resultsWe screened 15,554 titles and abstracts and 1384 full-text articles. Eight randomized clinical trials and 3 companion reports met our inclusion criteria. We found no significant effects of cognitive enhancers on cognition (Mini-Mental State Examination: 3 randomized clinical trials [RCTs], mean difference [MD] 0.14, 95% confidence interval [CI] -0.22 to 0.50; Alzheimer's Disease Assessment Scale - cognition subscale: 3 RCTs, standardized MD -0.07, 95% CI-0.16 to 0.01]) or function (Alzheimer's Disease Cooperative Study activities of daily living inventory: 2 RCTs, MD 0.30, 95% CI -0.26 to 0.86). Cognitive enhancers were associated with higher risks of nausea, diarrhea and vomiting than placebo.

interpretationCognitive enhancers did not improve cognition or function among patients with mild cognitive impairment and were associated with a greater risk of gastrointestinal harms. Our findings do not support the use of cognitive enhancers for mild cognitive impairment.

Indexed as

Cholinesterase InhibitorsCognitive DysfunctionDonepezilGalantamineHumansIndansMemantineNootropic AgentsPhenylcarbamatesPiperidinesRivastigmineTreatment OutcomeCholinesterase InhibitorsDonepezilGalantamineIndansMemantineNootropic AgentsPhenylcarbamatesPiperidinesRivastigmine

Identifiers

PMID24043661
PMCPMC3826344
OpenAlexW2131363930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.