ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2013
Chronic inflammation as a determinant of future aging phenotypes.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antioxidant and associated capacities of Camu camu (Myrciaria dubia): a systematic review.Journal of alternative and complementary medicine (New York, N.Y.) · 2015Pooled it
- Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial.Aging clinical and experimental research · 2022Trial
- The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults.The Journal of nutrition · 2018Trial
- Comparisons of the Postprandial Inflammatory and Endotoxaemic Responses to Mixed Meals in Young and Older Individuals: A Randomised Trial.Nutrients · 2017Trial
- Multimorbidity and functioning disparities in retired older adults: longitudinal trajectories, disease clusters, and mediating mechanisms.BMC geriatrics · 2026Article
- Early-life exposure to tobacco smoke increase risk of frailty in adulthood: evidence from a large prospective cohort study.Journal of translational medicine · 2025Article
- Boosting Immunity Through Nutrition and Gut Health: A Narrative Review on Managing Allergies and Multimorbidity.Nutrients · 2025Review
- Longitudinal analysis on inflammatory markers and frailty progression: based on the English longitudinal study of aging.European geriatric medicine · 2024Article
- The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms.Frontiers in pharmacology · 2024Review
- Bik promotes proteasomal degradation to control low-grade inflammation.The Journal of clinical investigation · 2023Article
- The rosetta stone of successful ageing: does oral health have a role?Biogerontology · 2023Review
- Review
- Systemic inflammation and subsequent risk of amyotrophic lateral sclerosis: Prospective cohort study.Brain, behavior, and immunity · 2023Article
- Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Systemic inflammation and subsequent risk of amyotrophic lateral sclerosis: prospective cohort study.medRxiv : the preprint server for health sciences · 2023Article
- Inflammatory biomarkers, multi-morbidity, and biologic aging.The Journal of international medical research · 2022Article
- Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes.Mechanisms of ageing and development · 2022Review
- Functional conservation in genes and pathways linking ageing and immunity.Immunity & ageing : I & A · 2021Review
- β-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice.Frontiers in pharmacology · 2021Article
- Inflammatory Markers and Plasma Fatty Acids in Predicting WBC Level Alterations in Association With Glucose-Related Markers: A Cross-Sectional Study.Frontiers in immunology · 2020Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe importance of chronic inflammation as a determinant of aging phenotypes may have been underestimated in previous studies that used a single measurement of inflammatory markers. We assessed inflammatory markers twice over a 5-year exposure period to examine the association between chronic inflammation and future aging phenotypes in a large population of men and women.
methodsWe obtained data for 3044 middle-aged adults (28.2% women) who were participating in the Whitehall II study and had no history of stroke, myocardial infarction or cancer at our study's baseline (1997-1999). Interleukin-6 was measured at baseline and 5 years earlier. Cause-specific mortality, chronic disease and functioning were ascertained from hospital data, register linkage and clinical examinations. We used these data to create 4 aging phenotypes at the 10-year follow-up (2007-2009): successful aging (free of major chronic disease and with optimal physical, mental and cognitive functioning), incident fatal or nonfatal cardiovascular disease, death from noncardiovascular causes and normal aging (all other participants).
resultsOf the 3044 participants, 721 (23.7%) met the criteria for successful aging at the 10-year follow-up, 321 (10.6%) had cardiovascular disease events, 147 (4.8%) died from noncardiovascular causes, and the remaining 1855 (60.9%) were included in the normal aging phenotype. After adjustment for potential confounders, having a high interleukin-6 level (> 2.0 ng/L) twice over the 5-year exposure period nearly halved the odds of successful aging at the 10-year follow-up (odds ratio [OR] 0.53, 95% confidence interval [CI] 0.38-0.74) and increased the risk of future cardiovascular events (OR 1.64, 95% CI 1.15-2.33) and noncardiovascular death (OR 2.43, 95% CI 1.58-3.80).
interpretationChronic inflammation, as ascertained by repeat measurements, was associated with a range of unhealthy aging phenotypes and a decreased likelihood of successful aging. Our results suggest that assessing long-term chronic inflammation by repeat measurement of interleukin-6 has the potential to guide clinical practice.
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