Common FABP4 genetic variants and plasma levels of fatty acid binding protein 4 in older adults.
Kenneth J Mukamal, Jemma B Wilk, Mary L Biggs, Majken K Jensen, Joachim H Ix, Jorge R Kizer, Russell P Tracy, Susan J Zieman, Dariush Mozaffarian, Bruce M Psaty and 2 more
Article in Lipids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
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3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
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5 · Who and what money
Authors and funding
12 authors at 9 institutions in 1 country.
Kenneth J MukamalDivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jemma B Wilk
Mary L Biggs
Majken K Jensen
Joachim H Ix
Jorge R Kizer
Russell P Tracy
Susan J Zieman
Dariush Mozaffarian
Bruce M Psaty
David S Siscovick
Luc Djoussé
Brigham and Women's Hospital · USHarvard University · USUniversity of Washington · USAlbert Einstein College of Medicine · USBeth Israel Deaconess Medical Center · USGroup Health Cooperative · USNational Institutes of Health · USUniversity of California, San Diego · USUniversity of Vermont · US
Funding
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
Determinants and Cardiovascular Consequences of Diabetes in Older AdultsR01HL094555 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ARNOLD, ALICE A., DJOUSSE, LUC · 2009 to 2012
$5.9M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Predictors of Alheimers Disease in Mild Cognitive ImpairmentR01AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2002 to 2011
$3.7M
BLOOD COAGULATION &FIBRINOLYSISR01HL065226 · NHLBI · SCRIPPS RESEARCH INSTITUTE · PI MACKMAN, NIGEL · 2000 to 2004
$1.8M
Hormonal trajectories in agingR01AG027058 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2006 to 2009
$1.2M
Predictors of Alzheimers Disease in Mild Cognitive ImpairmentR56AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2007 to 2007
$482k
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R56AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2010 to 2010
$300k
CHS-ULTRASOUND READINGN01HC045133 · HC · GEISINGER HEALTH SYSTEM · PI O'LEARY, DANIEL H. · 1994 to 2000
$155k
CHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
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CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
We examined common variants in the fatty acid binding protein 4 gene (FABP4) and plasma levels of FABP4 in adults aged 65 and older from the Cardiovascular Health Study. We genotyped rs16909187, rs1054135, rs16909192, rs10808846, rs7018409, rs2290201, and rs6992708 and measured circulating FABP4 levels among 3190 European Americans and 660 African Americans. Among European Americans, the minor alleles of six single nucleotide polymorphisms (SNP) were associated with lower FABP4 levels (all p ≤ 0.01). Among African Americans, the SNP with the lowest minor allele frequency was associated with lower FABP4 levels (p = 0.015). The C-A haplotype of rs16909192 and rs2290201 was associated with lower FABP4 levels in both European Americans (frequency = 16 %; p = 0.001) and African Americans (frequency = 8 %; p = 0.04). The haplotype combined a SNP in the first intron with one in the 3'untranslated region. However, the alleles associated with lower FABP4 levels were associated with higher fasting glucose in meta-analyses from the MAGIC consortium. These results demonstrate associations of common SNP and haplotypes in the FABP4 gene with lower plasma FABP4 but higher fasting glucose levels.
Indexed as
Polymorphism, Single NucleotideAgedAged, 80 and overBlack or African AmericanBlood GlucoseBody Mass IndexCohort StudiesFatty Acid-Binding ProteinsFemaleGene FrequencyGenetic Association StudiesHaplotypesHumansInsulinLinkage DisequilibriumMaleBlood GlucoseFABP4 protein, humanFatty Acid-Binding ProteinsInsulin
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Common FABP4 genetic variants and plasma levels of fatty acid binding protein 4 in older adults. · full record | OpenQuestion