ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2014
Species-specific activation of Cu/Zn SOD by its CCS copper chaperone in the pathogenic yeast Candida albicans.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- The Adaptation ofJournal of fungi (Basel, Switzerland) · 2023Article
- The role of manganese in morphogenesis and pathogenesis of the opportunistic fungal pathogen Candida albicans.PLoS pathogens · 2023Article
- Transcriptional response ofVirulence · 2021Article
- The Copper Chaperone CcsA, Coupled with Superoxide Dismutase SodA, Mediates the Oxidative Stress Response in Aspergillus fumigatus.Applied and environmental microbiology · 2021Article
- Nutritional immunity: targeting fungal zinc homeostasis.Heliyon · 2021Review
- The Negative Effect of Protein Phosphatase Z1 Deletion on the Oxidative Stress Tolerance ofJournal of fungi (Basel, Switzerland) · 2021Article
- Expanded role of the Cu-sensing transcription factor Mac1p in Candida albicans.Molecular microbiology · 2020Article
- Sclerotinia sclerotiorum utilizes host-derived copper for ROS detoxification and infection.PLoS pathogens · 2020Article
- Copper-only superoxide dismutase enzymes and iron starvation stress inThe Journal of biological chemistry · 2020Article
- Palmitic Acid Inhibits the Virulence Factors ofFrontiers in microbiology · 2020Article
- The Role of Copper Homeostasis at the Host-Pathogen Axis: From Bacteria to Fungi.International journal of molecular sciences · 2019Review
- Plasma membrane architecture protects Candida albicans from killing by copper.PLoS genetics · 2019Article
- Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.PLoS pathogens · 2018Article
- A role for Candida albicans superoxide dismutase enzymes in glucose signaling.Biochemical and biophysical research communications · 2018Article
- Metals in fungal virulence.FEMS microbiology reviews · 2018Review
- Fungi that Infect Humans.Microbiology spectrum · 2017Review
- The Iron-Dependent Regulation of the Candida albicans Oxidative Stress Response by the CCAAT-Binding Factor.PloS one · 2017Article
- Pho4 mediates phosphate acquisition in Candida albicans and is vital for stress resistance and metal homeostasis.Molecular biology of the cell · 2016Article
- Article
- An Adaptation to Low Copper in Candida albicans Involving SOD Enzymes and the Alternative Oxidase.PloS one · 2016Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Candida albicans is a pathogenic yeast of important public health relevance. Virulence of C. albicans requires a copper and zinc containing superoxide dismutase (SOD1), but the biology of C. albicans SOD1 is poorly understood. To this end, C. albicans SOD1 activation was examined in baker's yeast (Saccharomyces cerevisiae), a eukaryotic expression system that has proven fruitful for the study of SOD1 enzymes from invertebrates, plants, and mammals. In spite of the 80% similarity between S. cerevisiae and C. albicans SOD1 molecules, C. albicans SOD1 is not active in S. cerevisiae. The SOD1 appears incapable of productive interactions with the copper chaperone for SOD1 (CCS1) of S. cerevisiae. C. albicans SOD1 contains a proline at position 144 predicted to dictate dependence on CCS1. By mutation of this proline, C. albicans SOD1 gained activity in S. cerevisiae, and this activity was independent of CCS1. We identified a putative CCS1 gene in C. albicans and created heterozygous and homozygous gene deletions at this locus. Loss of CCS1 resulted in loss of SOD1 activity, consistent with its role as a copper chaperone. C. albicans CCS1 also restored activity to C. albicans SOD1 expressed in S. cerevisiae. C. albicans CCS1 is well adapted for activating its partner SOD1 from C. albicans, but not SOD1 from S. cerevisiae. In spite of the high degree of homology between the SOD1 and CCS1 molecules in these two fungal species, there exists a species-specific barrier in CCS-SOD interactions which may reflect the vastly different lifestyles of the pathogenic versus the noninfectious yeast.
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