Evidence map›Paper›PMID 24043440›Full record

ArticleAmerican journal of epidemiology2013

Association of hormonal contraceptive use with reduced levels of depressive symptoms: a national study of sexually active women in the United States.

Katherine M Keyes, Keely Cheslack-Postava, Carolyn Westhoff, Christine M Heim, Michelle Haloossim, Kate Walsh, Karestan Koenen

Open access · bronzeAbstract read
In one paragraph

Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 165 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Postpartum hormonal contraception use and incidence of postpartum depression: a systematic review.The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2019
    Pooled it
  4. Effects of three contraceptive methods on depression and sexual function: An ancillary study of the ECHO randomized trial.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021
    Trial
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  14. Beyond Birth Control: The Neuroscience of Hormonal Contraceptives.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Katherine M Keyes
Keely Cheslack-Postava
Carolyn Westhoff
Christine M Heim
Michelle Haloossim
Kate Walsh
Karestan Koenen
Columbia University · US

Funding

RESEARCH TRAINING PROGRAM IN PSYCHIATRIC EPIDEMIOLOGYT32MH013043 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Katherine M. Keyes · 1985 to 2026
$11.7M
Substance Abuse Epidemiology Training Program (SAETP) at Columbia UniversityT32DA031099 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DEBORAH S HASIN, Silvia Saboia Martins · 2012 to 2026
$6.1M
Race, alcohol consumption and vehicle crashes: an epidemiologic paradoxK01AA021511 · NIAAA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KEYES, KATHERINE M. · 2013 to 2017
$904k
NIAAA NIH HHS K01 AA021511NIAAA NIH HHS K01AA021511NIDA NIH HHS T32 DA031099NIMH NIH HHS T32 MH013043NIMH NIH HHS T32-MH13043
6 · The paper itself

Abstract

An estimated 80% of sexually active young women in the United States use hormonal contraceptives during their reproductive years. Associations between hormonal contraceptive use and mood disturbances remain understudied, despite the hypothesis that estrogen and progesterone play a role in mood problems. In this study, we used data from 6,654 sexually active nonpregnant women across 4 waves of the National Longitudinal Study of Adolescent Health (1994-2008), focusing on women aged 25-34 years. Women were asked about hormonal contraceptive use in the context of a current sexual partnership; thus, contraceptive users were compared with other sexually active women who were using either nonhormonal contraception or no contraception. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale. At ages 25-34 years, hormonal contraceptive users had lower mean levels of concurrent depressive symptoms (β = -1.04, 95% confidence interval: -1.73, -0.35) and were less likely to report a past-year suicide attempt (odds ratio = 0.37, 95% confidence interval: 0.14, 0.95) than women using low-efficacy contraception or no contraception, in models adjusted for propensity scores for hormonal contraceptive use. Longitudinal analyses indicated that associations between hormonal contraception and depressive symptoms were stable. Hormonal contraception may reduce levels of depressive symptoms among young women. Systematic investigation of exogenous hormones as a potential preventive factor in psychiatric epidemiology is warranted.

Indexed as

AdolescentAdultBody Mass IndexContraceptive Agents, FemaleDepressionEstrogensExerciseFemaleHealth BehaviorHealth StatusHumansLongitudinal StudiesProgestinsPropensity ScoreSexual BehaviorSmokingContraceptive Agents, FemaleEstrogensProgestinsadolescentdepressiongenderhormonal contraceptionoral contraceptivessuicide

Identifiers

PMID24043440
PMCPMC3888252
OpenAlexW2168522614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.