ArticleInternational urogynecology journal2014
Urethral striated muscle and extracellular matrix morphological characteristics among mildly diabetic pregnant rats: translational approach.
Article in International urogynecology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Ex vivo myo-mechanical assessment of isolated rectus abdominis muscle in pregnancy-specific urinary incontinence: a cross-sectional study nested within the Diamater cohort.Biomedical engineering online · 2025Article
- Urinary Incontinence in the Third Trimester of Pregnancy of Type 1 Diabetic Women.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Low back pain, pelvic pain, and associated factors in type 1 diabetic pregnant women.Clinics (Sao Paulo, Brazil) · 2024Observational
- The role of Gestational Diabetes Mellitus and pelvic floor 3D-ultrasound assessment during pregnancy predicting urinary incontinence: a prospective cohort study.BMC pregnancy and childbirth · 2023Article
- Advances in the molecular pathogenesis and cell therapy of stress urinary incontinence.Frontiers in cell and developmental biology · 2023Review
- Relaxin-2 during pregnancy according to glycemia, continence status, and pelvic floor muscle function.International urogynecology journal · 2022Article
- Transcriptomic Profiling of Rectus Abdominis Muscle in Women with Gestational Diabetes-Induced Myopathy: Characterization of Pathophysiology and Potential Muscle Biomarkers of Pregnancy-Specific Urinary Incontinence.International journal of molecular sciences · 2022Article
- Viability of ex-vivo myography as a diagnostic tool for rectus abdominis muscle electrical activity collected at Cesarean section within a diamater cohort study.Biomedical engineering online · 2022Article
- Reversal of diabetic-induced myopathy by swimming exercise in pregnant rats: a translational intervention study.Scientific reports · 2022Article
- Gestational diabetes is associated with alteration on pelvic floor muscle activation pattern during pregnancy and postpartum: Prospective cohort using electromyography assessment.Frontiers in endocrinology · 2022Article
- Review
- Study protocol to investigate biomolecular muscle profile as predictors of long-term urinary incontinence in women with gestational diabetes mellitus.BMC pregnancy and childbirth · 2020Article
- Article
- Negative impact of gestational diabetes mellitus on progress of pelvic floor muscle electromyography activity: Cohort study.PloS one · 2019Article
- Morphological changes in rat rectus abdominis muscle induced by diabetes and pregnancy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Streptozotocin-induced diabetes models: pathophysiological mechanisms and fetal outcomes.BioMed research international · 2014Review
- Neonatally induced mild diabetes: influence on development, behavior and reproductive function of female Wistar rats.Diabetology & metabolic syndrome · 2013Article
- Mild diabetes models and their maternal-fetal repercussions.Journal of diabetes research · 2013Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisDiabetes mellitus (DM) during pregnancy is associated with high levels of urinary incontinence (UI) and pelvic floor muscle dysfunction. Mild DM can lead to changes in urethral striated muscle and extracellular matrix (ECM) in pregnant rats considering both structures as an entire system responsible for urinary continence.
methodsNinety-two female Wistar rats were distributed in four experimental groups: virgin, pregnant, diabetic, and diabetic pregnant. In adult life, parental nondiabetic female rats were mated with nondiabetic male rats to obtain newborns. At the first day of birth, newborns received citrate buffer (nondiabetic group) or streptozotocin 100 mg/kg body weight, subcutaneous route (mild DM group). At day 21 of the pregnancy, the rats were lethally anesthetized and the urethra and vagina were extracted as a unit. Urethral and vaginal sections were cut and analyzed by: (a) cytochemical staining for ECM and muscle structural components, (b) immunohistochemistry to identify fast- and slow-muscle fibers, and (c) transmission electron microscopy for ultrastructural analysis of urethral striated muscle.
resultsIn comparison with the three control groups, variations in the urethral striated muscle and ECM from diabetic pregnant rats were observed including thinning, atrophy, fibrosis, increased area of blood vessels, mitochondria accumulation, increased lipid droplets, glycogen granules associated with colocalization of fast and slow fibers, and a steady decrease in the proportion of fast to slow fibers.
conclusionsMild DM and pregnancy can lead to a time-dependent disorder and tissue remodeling in which the urethral striated muscle and ECM has a fundamental function.
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