ArticleThe Journal of physiology2014
Inner retinal inhibition shapes the receptive field of retinal ganglion cells in primate.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Unraveling the role of asymmetric excitatory and inhibitory synaptic inputs to retinal ganglion cell direction selectivity.Frontiers in neuroscience · 2026Article
- Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Synchronous inhibitory pathways create both efficiency and diversity in the retina.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Synaptic inputs to broad thorny ganglion cells in macaque retina.The Journal of comparative neurology · 2021Article
- Wide-field amacrine cell inputs to ON parasol ganglion cells in macaque retina.The Journal of comparative neurology · 2020Article
- Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.Visual neuroscience · 2020Article
- Reductions in Calcium Signaling Limit Inhibition to Diabetic Retinal Rod Bipolar Cells.Investigative ophthalmology & visual science · 2019Article
- Cannabinoids Modulate Light Signaling in ON-Sustained Retinal Ganglion Cells of the Mouse.Frontiers in neural circuits · 2019Article
- General features of inhibition in the inner retina.The Journal of physiology · 2017Review
- Article
- Directionally selective retinal ganglion cells suppress luminance responses during natural viewing.Scientific reports · 2016Article
- Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.Journal of neurophysiology · 2016Article
- Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling.Investigative ophthalmology & visual science · 2016Article
- The impact of inhibitory mechanisms in the inner retina on spatial tuning of RGCs.Scientific reports · 2016Article
- Distinctive receptive field and physiological properties of a wide-field amacrine cell in the macaque monkey retina.Journal of neurophysiology · 2015Article
- GlyRα2, not GlyRα3, modulates the receptive field surround of OFF retinal ganglion cells.Visual neuroscience · 2015Article
- A simpler primate brain: the visual system of the marmoset monkey.Frontiers in neural circuits · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The centre-surround organisation of receptive fields is a feature of most retinal ganglion cells (RGCs) and is critical for spatial discrimination and contrast detection. Although lateral inhibitory processes are known to be important in generating the receptive field surround, the contribution of each of the two synaptic layers in the primate retina remains unclear. Here we studied the spatial organisation of excitatory and inhibitory synaptic inputs onto ON and OFF ganglion cells in the primate retina. All RGCs showed an increase in excitation in response to stimulus of preferred polarity. Inhibition onto RGCs comprised two types of responses to preferred polarity: some RGCs showed an increase in inhibition whilst others showed removal of tonic inhibition. Excitatory inputs were strongly spatially tuned but inhibitory inputs showed more variable organisation: in some neurons they were as strongly tuned as excitation, and in others inhibitory inputs showed no spatial tuning. We targeted one source of inner retinal inhibition by functionally ablating spiking amacrine cells with bath application of tetrodotoxin (TTX). TTX significantly reduced the spatial tuning of excitatory inputs. In addition, TTX reduced inhibition onto those RGCs where a stimulus of preferred polarity increased inhibition. Reconstruction of the spatial tuning properties by somatic injection of excitatory and inhibitory synaptic conductances verified that TTX-mediated inhibition onto bipolar cells increases the strength of the surround in RGC spiking output. These results indicate that in the primate retina inhibitory mechanisms in the inner plexiform layer sharpen the spatial tuning of ganglion cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.