ArticleScientific reports2013
In situ recognition of cell-surface glycans and targeted imaging of cancer cells.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 61 citations in OpenAlex.
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- Merging the Versatile Functionalities of Boronic Acid with Peptides.International journal of molecular sciences · 2021Review
- Lessons in Organic Fluorescent Probe Discovery.Chembiochem : a European journal of chemical biology · 2021Review
- Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies.ACS omega · 2021Article
- Electrochemical Sensors for Detection of Markers on Tumor Cells.International journal of molecular sciences · 2021Review
- Selective Sugar Recognition by Anthracene-Type Boronic Acid Fluorophore/Cyclodextrin Supramolecular Complex Under Physiological pH Condition.Frontiers in chemistry · 2019Article
- Recent development of boronic acid-based fluorescent sensors.RSC advances · 2018Review
- Article
- Different expression levels of glycans on leukemic cells-a novel screening method with molecularly imprinted polymers (MIP) targeting sialic acid.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Cancer cells remodel themselves and vasculature to overcome the endothelial barrier.Cancer letters · 2016Review
- Systemic localization of seven major types of carbohydrates on cell membranes by dSTORM imaging.Scientific reports · 2016Article
- Cell surface engineering to control cellular interactions.ChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2016Article
- Controlled positioning of analytes and cells on a plasmonic platform for glycan sensing using surface enhanced Raman spectroscopy.Chemical science · 2016Article
- A Multichannel Biosensor for Rapid Determination of Cell Surface Glycomic Signatures.ACS central science · 2015Article
- Detection and characterization of cancer cells and pathogenic bacteria using aptamer-based nano-conjugates.Sensors (Basel, Switzerland) · 2014Article
- Boronic acids for sensing and other applications - a mini-review of papers published in 2013.Chemistry Central journal · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescent sensors capable of recognizing cancer-associated glycans, such as sialyl Lewis X (sLe(x)) tetrasaccharide, have great potential for cancer diagnosis and therapy. Studies on water-soluble and biocompatible sensors for in situ recognition of cancer-associated glycans in live cells and targeted imaging of cancer cells are very limited at present. Here we report boronic acid-functionalized peptide-based fluorescent sensors (BPFSs) for in situ recognition and differentiation of cancer-associated glycans, as well as targeted imaging of cancer cells. By screening BPFSs with different structures, it was demonstrated that BPFS₁ with a FRGDF peptide could recognize cell-surface glycan of sLe(x) with high specificity and thereafter fluorescently label and discriminate cancer cells through the cooperation with the specific recognition between RGD and integrins. The newly developed peptide-based sensor will find great potential as a fluorescent probe for cancer diagnosis.
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