ArticleJournal of the American Heart Association2013
Leptin-induced endothelial dysfunction is mediated by sympathetic nervous system activity.
Article in Journal of the American Heart Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- A Review of Emerging Biomarkers Connecting Diabetes and Ischemic Stroke: Implications for Early Detection and Risk Stratification.Journal of diabetes research · 2026Review
- Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Chinese visceral adiposity index predicts all-cause mortality in patients with type 2 diabetes, heart failure, and chronic kidney disease: a retrospective cohort study.BMC research notes · 2025Article
- Sex-Specific Differences in the Pathophysiology of Hypertension.Biomolecules · 2025Review
- Hypertension among persons living with HIV/AIDS and its association with HIV-related health factors.AIDS research and therapy · 2024Article
- The Mechanism of Kelulut Honey in Reversing Metabolic Changes in Rats Fed with High-Carbohydrate High-Fat Diet.Molecules (Basel, Switzerland) · 2023Article
- Obesity-induced ocular changes in children and adolescents: A review.Frontiers in pediatrics · 2023Review
- Endothelial leptin receptor is dispensable for leptin-induced sympatho-activation and hypertension in male mice.Vascular pharmacology · 2022Article
- Regulation of acute reflectory hyperinflammation in viral and other diseases by means of stellate ganglion block. A conceptual view with a focus on Covid-19.Autonomic neuroscience : basic & clinical · 2022Review
- Carotid Arterial Stiffness and Cardiometabolic Profiles in Women with Fibromyalgia.Biomedicines · 2021Article
- Increased ambulatory arterial stiffness index and blood pressure load in normotensive obese patients.African health sciences · 2021Article
- Cancer and comorbidity: The role of leptin in breast cancer and associated pathologies.World journal of clinical cases · 2018Review
- Hypertension in HIV-Infected Adults: Novel Pathophysiologic Mechanisms.Hypertension (Dallas, Tex. : 1979) · 2018Review
- Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3.Archives of medical science : AMS · 2017Article
- A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk.Current hypertension reports · 2016Review
- Vascular smooth muscle-specific deletion of the leptin receptor attenuates leptin-induced alterations in vascular relaxation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Association of serum leptin levels with central arterial stiffness in coronary artery disease patients.BMC cardiovascular disorders · 2016Article
- Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.Circulation. Heart failure · 2016Article
- Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells.Endocrine · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe adipocyte-derived hormone leptin is elevated in obesity and may contribute to vascular risk associated with obesity. The mechanism(s) by which leptin affects vascular disease is unclear, although leptin has been shown to increase sympathetic activity. The aim of this study was to investigate the effect of leptin treatment on endothelial function and the role of the local sympathetic nervous system in mediating these effects. METHODS AND
resultsRecombinant leptin was administered to C57BL6/J mice every other day for 1 week. Mesenteric arteriole myography revealed that leptin treatment caused significant impairment of endothelium-dependent vasorelaxation. Although leptin alone did not raise aortic blood pressure, leptin treatment augmented the blood pressure response to angiotensin II. The effects of leptin on mesenteric arteriolar function and aortic blood pressure response to angiotensin II were neutralized following sympathetic denervation to the mesenteric vasculature. The superoxide scavenger TEMPOL was also effective in preventing the effects of leptin on endothelial dysfunction.
conclusionsLeptin causes endothelial dysfunction and enhances the effects of angiotensin II on blood pressure. These effects of leptin are mediated by sympathetic nervous system activation and superoxide and may contribute to vascular stiffness and hypertension in obesity.
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