Evidence map›Paper›PMID 24042051›Full record

ArticleFEBS letters2013

Coronary heart disease alters intercellular communication by modifying microparticle-mediated microRNA transport.

Nnenna A Finn, Danny Eapen, Pankaj Manocha, Hatem Al Kassem, Bernard Lassegue, Nima Ghasemzadeh, Arshed Quyyumi, Charles D Searles

Open access · bronzeAbstract read
In one paragraph

Article in FEBS letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Extracellular vesicles related to familial hypercholesterolemia.Archives of endocrinology and metabolism · 2026
    Article
  2. Article
  3. Review
  4. MicroRNAs and Cardiovascular Disease Risk.Current cardiology reports · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Extracellular Vesicles as Messengers in Atherosclerosis.Journal of cardiovascular translational research · 2020
    Review
  9. The Origin and Pathogenesis of Endometriosis.Annual review of pathology · 2020
    Review
  10. The diagnostic value of circulating microRNAs in heart failure.Experimental and therapeutic medicine · 2019
    Review
  11. Review
  12. Article
  13. Article
  14. MicroRNA Biomarkers for Coronary Artery Disease?Current atherosclerosis reports · 2015
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nnenna A FinnDivision of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Danny Eapen
Pankaj Manocha
Hatem Al Kassem
Bernard Lassegue
Nima Ghasemzadeh
Arshed Quyyumi
Charles D Searles
Emory University · US

Funding

Metabolomics of subclinical and clinical cardiovascular diseaseP20HL113451 · NHLBI · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2012 to 2016
$4.3M
Modulation of Endothelial Cell Function by the Shear Stress-Responsive miR-155R01HL109559 · NHLBI · EMORY UNIVERSITY · PI SEARLES, CHARLES D · 2011 to 2014
$1.3M
The Impact of miR-21 Expression on Endothelial Cell Apoptosis and InflammationI01BX000704 · VA · VETERANS HEALTH ADMINISTRATION · PI SEARLES, CHARLES D · 2011 to 2014
–
BLRD VA I01 BX000704NHLBI NIH HHS HHSN268201000043CNHLBI NIH HHS P20 HL113451NHLBI NIH HHS R01 HL109559
6 · The paper itself

Abstract

Coronary heart disease (CHD) is characterized by abnormal intercellular communication and circulating microRNAs (miRNAs) are likely involved in this process. Here, we show that CHD was associated with changes in the transport of circulating miRNA, particularly decreased miRNA enrichment in microparticles (MPs). Additionally, MPs from CHD patients were less efficient at transferring miRNA to cultured HUVECs, which correlated with their diminished capacity to bind developmental endothelial locus-1 (Del-1). In summary, CHD was associated with distinct changes in circulating miRNA transport and these changes may contribute to the abnormal intercellular communication that underlies CHD initiation and progression.

Indexed as

Cell CommunicationAdolescentAdultBinding SitesBiological TransportCalcium-Binding ProteinsCarrier ProteinsCell Adhesion MoleculesCoronary DiseaseFemaleHumansHuman Umbilical Vein Endothelial CellsMaleMicroRNAsMiddle AgedReal-Time Polymerase Chain ReactionCalcium-Binding ProteinsCarrier ProteinsCell Adhesion MoleculesEDIL3 protein, humanMicroRNAsaggregated proteinAPAtherosclerosisCHDcoronary heart diseaseCoronary heart diseaseDel-1developmental endothelial locus-1Developmental endothelial locus-1ExoexosomesIntercellular signalinglipoproteinLPmicroparticlesMicroparticlesMicroRNAMP/MPsRFrisk factor

Identifiers

PMID24042051
PMCPMC3910498
OpenAlexW1986017932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.