Evidence map›Paper›PMID 24041868›Full record

ArticleCancer letters2014

Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides.

Neelu Puri, Ryan T Pitman, Richard E Mulnix, Terrianne Erickson, Audra N Iness, Connie Vitali, Yutong Zhao, Ravi Salgia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. The Role of Telomerase in Breast Cancer's Response to Therapy.International journal of molecular sciences · 2022
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. [Relationship between thrombospondin-1 and the occurrence and development of oral and maxillofacial malignancy].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018
    Review
  8. Review
  9. Review
  10. Treating Cancer by Targeting Telomeres and Telomerase.Antioxidants (Basel, Switzerland) · 2017
    Review
  11. Review
  12. Article
  13. Article
  14. T-oligo as an anticancer agent in colorectal cancer.Biochemical and biophysical research communications · 2014
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Neelu PuriDepartment of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL, United States. Electronic address: neelupur@uic.edu.
Ryan T PitmanDepartment of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL, United States.
Richard E MulnixDepartment of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL, United States.
Terrianne EricksonDepartment of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL, United States.
Audra N InessDepartment of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL, United States.
Connie VitaliDepartment of Pathology, University of Illinois College of Medicine, Rockford, IL, United States.
Yutong ZhaoDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care, University of Pittsburgh, Pittsburgh, PA, United States.
Ravi SalgiaDepartment of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, United States.
Illinois College · USUniversity of Chicago · USUniversity of Pittsburgh · US

Funding

Lysophosphatidic Acid in Airway Barrier Function and RemodelingR01HL091916 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHAO, YUTONG · 2009 to 2013
$1.8M
Regulation of the IL-33 receptor, ST2L, by Protein Stability in Septic InjuryR01HL112791 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHAO, YUTONG · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL091916NHLBI NIH HHS R01 HL112791
6 · The paper itself

Abstract

Exposure of the telomere overhang acts as a DNA damage signal, and exogenous administration of an 11-base oligonucleotide homologous to the 3'-telomere overhang sequence (T-oligo) mimics the effects of overhang exposure by inducing senescence and cell death in non-small cell lung cancer (NSCLC) cells, but not in normal bronchial epithelial cells. T-oligo-induced decrease in cellular proliferation in NSCLC is likely directed through both p53 and its homolog, p73, with subsequent induction of senescence and expression of senescence-associated proteins, p21, p33(ING), and p27(Kip1) both in vivo and in vitro. Additionally, T-oligo decreases tumor size and inhibits angiogenesis through decreased VEGF signaling and increased TSP-1 expression.

Indexed as

DNA DamageGenetic Predisposition to DiseaseNeovascularization, PathologicAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBronchiCarcinoma, Non-Small-Cell LungCell Line, TumorCell ProliferationCellular SenescenceCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27Epithelial CellsGene Expression Regulation, NeoplasticHumansInhibitor of Growth Protein 1Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27ING1 protein, humanInhibitor of Growth Protein 1Intracellular Signaling Peptides and ProteinsNuclear ProteinsOligonucleotidesSPZ1 protein, humanTumor Suppressor ProteinsVascular Endothelial Growth Factor AVEGFA protein, humanAngiogenesisApoptosisLung cancerp53SenescenceTelomere overhang

Identifiers

PMID24041868
PMCPMC5839143
OpenAlexW2161277166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.