Evidence map›Paper›PMID 24041495›Full record

ReviewJournal of insect physiology2013

Towards the elements of successful insect RNAi.

Jeffrey G Scott, Kristin Michel, Lyric C Bartholomay, Blair D Siegfried, Wayne B Hunter, Guy Smagghe, Kun Yan Zhu, Angela E Douglas

Abstract readReview
In one paragraph

Review in Journal of insect physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

191 citing papers in PubMed.

  1. Article
  2. Review
  3. EngineeredInsects · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Targeting elongation factor 2 inFrontiers in insect science · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeffrey G ScottDepartment of Entomology, Cornell University, Ithaca, NY 14853, USA.
Kristin Michel
Lyric C Bartholomay
Blair D Siegfried
Wayne B Hunter
Guy Smagghe
Kun Yan Zhu
Angela E Douglas

Funding

The protein nutrition of the symbiotic system between /Drosophila/and its gut micR01GM095372 · NIGMS · CORNELL UNIVERSITY · PI SEARLE, ANGELA E · 2011 to 2019
$2.8M
The function(s) of serpin-2 in mosquito immunity and physiologyR01AI095842 · NIAID · KANSAS STATE UNIVERSITY · PI MICHEL, KRISTIN · 2011 to 2014
$1.5M
NIAID NIH HHS R01 AI095842NIGMS NIH HHS R01 GM095372
6 · The paper itself

Abstract

RNA interference (RNAi), the sequence-specific suppression of gene expression, offers great opportunities for insect science, especially to analyze gene function, manage pest populations, and reduce disease pathogens. The accumulating body of literature on insect RNAi has revealed that the efficiency of RNAi varies between different species, the mode of RNAi delivery, and the genes being targeted. There is also variation in the duration of transcript suppression. At present, we have a limited capacity to predict the ideal experimental strategy for RNAi of a particular gene/insect because of our incomplete understanding of whether and how the RNAi signal is amplified and spread among insect cells. Consequently, development of the optimal RNAi protocols is a highly empirical process. This limitation can be relieved by systematic analysis of the molecular physiological basis of RNAi mechanisms in insects. An enhanced conceptual understanding of RNAi function in insects will facilitate the application of RNAi for dissection of gene function, and to fast-track the application of RNAi to both control pests and develop effective methods to protect beneficial insects and non-insect arthropods, particularly the honey bee (Apis mellifera) and cultured Pacific white shrimp (Litopenaeus vannamei) from viral and parasitic diseases.

Indexed as

RNA InterferenceAnimalsInsectaInsect ControlAntiviral therapydsRNAInsect pest controlRNA interferencesiRNASystemic RNAi

Identifiers

PMID24041495
PMCPMC3870143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.