ArticleBiomaterials2013
Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes.Bioengineering (Basel, Switzerland) · 2025Article
- Dimensionality Matters: Exploiting UV-Photopatterned 2D and Two-Photon-Printed 2.5D Contact Guidance Cues to Control Corneal Fibroblast Behavior and Collagen Deposition.Bioengineering (Basel, Switzerland) · 2024Article
- Mechanical Properties of Bioengineered Corneal Stroma.Advanced healthcare materials · 2021Review
- A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei.Nature protocols · 2021Article
- Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility.Translational vision science & technology · 2020Article
- Physical limits to sensing material properties.Nature communications · 2020Article
- Multifunctional synthetic Bowman's membrane-stromal biomimetic for corneal reconstruction.Biomaterials · 2020Article
- Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma.Nature communications · 2020Article
- Single-cell morphology encodes metastatic potential.Science advances · 2020Article
- Review
- Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants.Advanced functional materials · 2018Article
- 3D bioprinting of a corneal stroma equivalent.Experimental eye research · 2018Article
- Physical limits to biomechanical sensing in disordered fibre networks.Nature communications · 2017Article
- Biophysical and biomolecular determination of cellular age in humans.Nature biomedical engineering · 2017Article
- MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents.Oncogene · 2016Article
- Lung-On-A-Chip Technologies for Disease Modeling and Drug Development.Biomedical engineering and computational biology · 2016Review
- Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions.Oncotarget · 2015Article
- The Mechanobiology of Aging.Annual review of biomedical engineering · 2015Review
- Application of retinoic acid improves form and function of tissue engineered corneal construct.Organogenesis · 2015Article
- Biomaterials and Tissue Engineering Strategies for Conjunctival Reconstruction and Dry Eye Treatment.Middle East African journal of ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Type I collagen membranes with tailored fibril nanoarchitectures were fabricated through a vitrification processing, which mimicked, to a degree, the collagen maturation process of corneal stromal extracellular matrix in vivo. Vitrification was performed at a controlled temperature of either 5 °C or 39 °C at a constant relative humidity of 40% for various time periods from 0.5 wk up to 8 wk. During vitrification, the vitrified collagen membranes (collagen vitrigels, CVs) exhibited a rapid growth in fibrillar density through the evaporation of water and an increase in fibrillar stiffness due to the formation of new and/or more-stable interactions. On the other hand, the collagen fibrils in CVs maintained their D-periodicity and showed no significant difference in fibrillar diameter, indicating preservation of the native states of the collagen fibrils during vitrification. Keratocyte phenotype was maintained on CVs to varying degrees that were strongly influenced by the collagen fibril nanoarchitectures. Specifically, the vitrification time of CVs mainly governed the keratocyte morphology, showing significant increases in the cell protrusion number, protrusion length, and cell size along with CV vitrification time. The CV vitrification temperature affected the regulation of keratocyte fibroblasts' gene expressions, including keratocan and aldehyde dehydrogenase (ALDH), demonstrating a unique way to control the expression of specific genes in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.