ArticlePsychological medicine2014
White-matter tract integrity in late-life depression: associations with severity and cognition.
Article in Psychological medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Brain-cognition relationships in late-life depression: a systematic review of structural magnetic resonance imaging studies.Translational psychiatry · 2023Pooled it
- Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review.Frontiers in neuroscience · 2020Pooled it
- State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome.Journal of the American Geriatrics Society · 2018Pooled it
- The efficacy of transcranial random noise stimulation (tRNS) on mood may depend on individual differences including age and trait mood.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Trial
- Brain-cognition relationships and treatment outcome in treatment-resistant late-life depression.Nature communications · 2026Article
- Neurobiological and therapeutic landmarks of depression associated with Alzheimer's disease dementia.Frontiers in aging neuroscience · 2025Review
- The mediating effect of the amygdala-frontal circuit on the association between depressive symptoms and cognitive function in Alzheimer's disease.Translational psychiatry · 2024Article
- Association of white matter hyperintensities and clinical vascular burden with depressive symptoms in Black older adults.International journal of geriatric psychiatry · 2024Article
- Neuroimaging features of depression-frailty phenotype in older adults: a pilot study.International psychogeriatrics · 2023Article
- White matter abnormalities are associated with the declined ability of reasoning and problem-solving in major depressive disorder.Brain and behavior · 2023Article
- EPI susceptibility correction introduces significant differences far from local areas of high distortion.Magnetic resonance imaging · 2022Article
- Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression.Frontiers in aging neuroscience · 2022Article
- Default mode network dissociation linking cerebral beta amyloid retention and depression in cognitively normal older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- Memantine can protect against inflammation-based cognitive decline in geriatric depression.Brain, behavior, & immunity - health · 2020Article
- Changes of Altruistic Behavior and Kynurenine Pathway in Late-Life Depression.Frontiers in psychiatry · 2020Article
- Differences in Cerebral Structure Associated With Depressive Symptoms in the Elderly With Alzheimer's Disease.Frontiers in aging neuroscience · 2020Article
- The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults.Neuropsychologia · 2019Article
- White matter abnormalities predict residual negative self-referential thinking following treatment of late-life depression with escitalopram: A preliminary study.Journal of affective disorders · 2019Article
- Linking late life depression and Alzheimer's disease: mechanisms and resilience.Current behavioral neuroscience reports · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAlthough significant changes in both gray and white matter have been noted in late-life depression (LLD), the pathophysiology of implicated white-matter tracts has not been fully described. In this study we examined the integrity of specific white-matter tracts in LLD versus healthy controls (HC).
methodParticipants aged ⩾60 years were recruited from the community. The sample included 23 clinically diagnosed individuals with LLD and 23 HC. White-matter integrity metrics [fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)] were calculated in the bilateral cingulum and uncinate fasciculus. Depression severity was measured using the Center for Epidemiological Studies Depression Scale (CESD). Composite scores for learning and memory and executive function were created using standardized neuropsychological assessments.
resultsWhite-matter integrity was lower in LLD versus HC in the bilateral cingulum and right uncinate fasciculus (p⩽0.05). In the whole sample, depression severity correlated with integrity in the bilateral cingulum and right uncinate fasciculus (p ⩽0.05). In patients, depression severity correlated with the integrity of the left uncinate fasciculus (p = 0.03); this tract also correlated with executive function (p = 0.02). Among HC, tract integrity did not correlate with depression scores; however, learning and memory correlated with integrity of the bilateral uncinate fasciculus and bilateral cingulum; executive function correlated with the right uncinate and left cingulum (p ⩽0.05).
conclusionsWhite-matter tract integrity was lower in LLD than in HC and was associated with depression severity across all participants. Tract integrity was associated with cognition in both groups but more robustly among HC.
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