ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2013
Effects of multimodal analgesia with LowDose buprenorphine and meloxicam on fecal glucocorticoid metabolites after surgery in New Zealand white rabbits (Oryctolagus cuniculus).
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- D-ribose-loaded hydrogel modulates necrosis progression and wound stability in a rabbit random-pattern skin flap model.JPRAS open · 2026Article
- Methodological differences in fecal corticosterone metabolite extraction in pet rabbits: implications for welfare assessment.Frontiers in veterinary science · 2026Article
- Pharmacokinetic Evaluation of Topical Long-Acting Buprenorphine in New Zealand White Rabbits (Oryctolagus cuniculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery.Animals : an open access journal from MDPI · 2025Article
- Measurement of Cyclooxygenase Products in Plasma as Markers for Inhibition of Cyclooxygenase Isoforms by Oral Meloxicam in New Zealand White Rabbits (Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Therapeutic Effect of Acupotomy at Sanheyang for Cartilage Collagen Damage in Moderate Knee Osteoarthritis: A Rabbit Model.Journal of inflammation research · 2023Article
- Effects of Buprenorphine Treatment on Influenza Pathogenesis in the Ferret (Comparative medicine · 2022Article
- Evaluating Pain and Analgesia Effectiveness Following Routine Castration in Rabbits Using Behavior and Facial Expressions.Frontiers in veterinary science · 2022Article
- Additional Assessment of Fecal Corticosterone Metabolites Improves Visual Rating in the Evaluation of Stress Responses of Laboratory Rats.Animals : an open access journal from MDPI · 2021Article
- Article
- Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits.BMC veterinary research · 2020Article
- A Comparison of Buprenorphine, Sustained release Buprenorphine, and High concentration Buprenorphine in Male New Zealand White Rabbits.Journal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Reliability and construct validity of a composite pain scale for rabbit (CANCRS) in a clinical environment.PloS one · 2020Article
- Administration of Tramadol or Buprenorphine via the drinking water for post-operative analgesia in a mouse-osteotomy model.Scientific reports · 2019Article
- Evaluation of Pain Assessment Techniques and Analgesia Efficacy in a Female Guinea Pig (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Ventral rhinotomy in a pet rabbit (Oryctolagus cuniculus) with an odontogenic abscess and sub-obstructive rhinitis.The Canadian veterinary journal = La revue veterinaire canadienne · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the increasing use of rabbits as companion animals and models for biomedical research, rabbits have not been extensively studied to identify an efficacious postsurgical analgesic that does not cause systemic complications. The synergy of NSAID and systemic opioids is well-documented, and their combined use reduces the amount of either drug required for adequate analgesia. We measured fecal corticosterone metabolites (FCM) in rabbits after a minimally invasive vascular cut-down procedure. Rabbits received buprenorphine (0.03 mg/kg SC every 12 h for 3 d), meloxicam (0.2 mg/kg SC every 24 h for 3 d), buprenorphine-meloxicam (0.01 mg/kg-0.1 mg/kg SC every 24 h for 3 d), or a single dose of 0.5% bupivacaine (0.5 mL) infused locally at the incision site. By day 3 after surgery, buprenorphine, meloxicam, and bupivacaine groups showed elevated FCM levels, which continued to rise until day 7 and then gradually returned to baseline by day 28. In the buprenorphine-meloxicam group, FCM was relatively unchanged until day 3, when treatment was discontinued, and then began to rise. Rabbits in the buprenorphine-meloxicam group gained more weight over the 28-d study than did those in the other 3 treatment groups. This study shows that in rabbits low-dose buprenorphine administered with meloxicam effectively mitigates the FCM response that develops after surgery without the adverse effects associated with higher doses.
Indexed as
Identifiers
24041213PMC3784663W2148151416What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.