ReviewCNS & neurological disorders drug targets2013
Suicide and the polyamine system.
Review in CNS & neurological disorders drug targets, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Pharmacogenes Associated with Suicidal Behavior: Addressing a Potential Therapeutic Window.Actas espanolas de psiquiatria · 2026Review
- Genetic predisposition of suicidal behavior: variants in GRIN2B, GABRG2, and ODC1 genes in attempted and completed suicide in two Balkan populations.European archives of psychiatry and clinical neuroscience · 2025Article
- Structure and mechanism of human vesicular polyamine transporter.Nature communications · 2025Article
- Altered Arginine/Agmatine Pathway and Polyamines in Adolescents Diagnosed with Major Depressive Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Unveiling the hidden players: noncoding RNAs orchestrating polyamine metabolism in disease.Cell & bioscience · 2024Review
- Suicidal behavior-advances in clinical and neurobiological research and improvement of prevention strategies.World journal of psychiatry · 2022Article
- Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder.Biomedicines · 2022Article
- Molecular characterization of depression trait and state.Molecular psychiatry · 2022Article
- Psychotropic drugs interaction with the lipid nanoparticle of COVID-19 mRNA therapeutics.Frontiers in pharmacology · 2022Article
- Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy.World journal of psychiatry · 2021Review
- Metabolic Alterations Associated with γ-Hydroxybutyric Acid and the Potential of Metabolites as Biomarkers of Its Exposure.Metabolites · 2021Review
- Commensal Microbiota Regulation of Metabolic Networks During Olfactory Dysfunction in Mice.Neuropsychiatric disease and treatment · 2020Article
- Adolescent Suicide as a Failure of Acute Stress-Response Systems.Annual review of clinical psychology · 2019Review
- Metabolomic study of polyamines in rat urine following intraperitoneal injection of γ-hydroxybutyric acid.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Neuropathology of suicide: recent findings and future directions.Molecular psychiatry · 2017Review
- Altered brain arginine metabolism in schizophrenia.Translational psychiatry · 2016Article
- An overview of the neurobiology of suicidal behaviors as one meta-system.Molecular psychiatry · 2015Review
- Polyamines and suicide risk.Molecular psychiatry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Suicide is a significant worldwide public health problem. Understanding the neurobiology is important as it can help us to better elucidate underlying etiological factors and provide opportunities for intervention. In recent years, many lines of research have suggested that the polyamine system may be dysregulated in suicidal behaviors. Initial research in animals provided evidence of a dysfunctional polyamine stress response system, while later work using post-mortem human brain tissue has suggested that molecular mechanisms may be at play in the suicide brain. In this review, we will describe the research that suggests the presence of alterations in the polyamine system in mental disorders and behavioral phenotypes, with particular attention to work on suicide. In addition, we will also describe potential avenues for future work.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.