ArticleInternational journal of clinical and experimental medicine2013
Circulating levels of erythropoietin and its relation to arterial stiffness in patients with hypertension.
Article in International journal of clinical and experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
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- Evaluation of early arterial wall lesions by elastography parameters in spontaneously hypertensive rats.BMC cardiovascular disorders · 2023Article
- Osteoporosis biomarkers act as predictors for diagnosis of chronic renal insufficiency in elder patients.International journal of clinical and experimental medicine · 2015Article
- Impairment of myocardial functions and arterial stiffness in patients with lichen planus.Anais brasileiros de dermatologiaArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging experimental and clinical data indicates that erythropoietin (EPO) have significant roles in the cardiovascular system. But the relationship between endogenous EPO levels and arterial stiffness remains unknown. We investigated the EPO levels in relation to arterial stiffness parameters in patients with never treated newly diagnosed hypertension (HT).
methodsWe studied 42 (47.8 ± 10 years) never treated HT patients and age and gender-matched 40 (47 ± 8.6 years) normotensive individuals. Serum EPO levels were determined in all subjects using the chemiluminescence immunoassay kit. We evaluated heart rate-corrected augmentation index (AIx@75), a marker of wave reflections and aortic pulse wave velocity (PWV) as indices of elastic-type aortic stiffness using applanation tonometry (Sphygmocor).
resultsThe levels of EPO were not significantly different in hypertensive patients and the controls (10.6 ± 5 vs. 11.6 ± 9, mIU/mL, p = 0.5). Aortic PWV (10.3 ± 2.3 vs. 8.7 ± 1.6 m/s, p = 0.0001) and AIx@75 (22.7 ± 10 vs. 15 ± 11, %, p = 0.002) were significantly higher in hypertensive patients than the controls. EPO levels were not correlated with brachial and central pressures. Also EPO level was not significantly correlated with AIx@75 (r = -0.15, p = 0.17) and aortic PWV (r = -0.16, p = 0.13).
conclusionResults from this study indicate that endogenous EPO levels may not be a factor in development of increased arterial stiffness.
Indexed as
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24040481PMC3762628W198276325What OpenQuestion holds
Registered trials
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