ArticleInternational journal of clinical and experimental pathology2013
IL-22 secreted by decidual stromal cells and NK cells promotes the survival of human trophoblasts.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
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- Embryo-maternal cross-talk: key players in successful implantation and live birth rates.Reproductive biology and endocrinology : RB&E · 2025Review
- Dysregulation of Treg/Th17 Balance and Intracellular Expression of IL-21 and IL-22 in the Pathogenesis of Gestational Hypertension.Journal of clinical medicine · 2025Article
- I don't know about you, but I'm feeling IL-22.Cytokine & growth factor reviews · 2024Review
- Multi-locus high-risk alleles association from interleukin's genes with female infertility and certain comorbidities.BMC research notes · 2024Article
- Immune Cell Functionality during Decidualization and Potential Clinical Application.Life (Basel, Switzerland) · 2023Review
- Endometrial Inflammation and Impaired Spontaneous Decidualization: Insights into the Pathogenesis of Adenomyosis.International journal of environmental research and public health · 2023Review
- Recurrent Abortion and the Involvement of Killer-Cell Immunoglobulin-like Receptor (KIR) Genes, Activated T Cells, NK Abnormalities, and Cytokine Profiles.Journal of clinical medicine · 2023Review
- Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto's Thyroiditis.Journal of immunology research · 2023Article
- Immunological Changes in Pregnancy and Prospects of Therapeutic Pla-Xosomes in Adverse Pregnancy Outcomes.Frontiers in pharmacology · 2022Review
- IL-22 regulates endometrial regeneration by enhancing tight junctions and orchestrating extracellular matrix.Frontiers in immunology · 2022Article
- The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy.Frontiers in immunology · 2022Review
- The Role of Immune Cells in Recurrent Spontaneous Abortion.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction.Frontiers in immunology · 2021Review
- Innate lymphoid cells are reduced in pregnant HIV positive women and are associated with preterm birth.Scientific reports · 2020Article
- The expression and biological function of chemokine CXCL12 and receptor CXCR4/CXCR7 in placenta accreta spectrum disorders.Journal of cellular and molecular medicine · 2020Article
- T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells.Frontiers in immunology · 2020Review
- Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy.International journal of biological sciences · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-22 (IL-22) has been implicated as an important immune regulator in many physiologic and pathological processes, but little is known about the IL-22 in the fetal-maternal interface. In this study, we demonstrated that co-culture of decidual stromal cells (DSCs) and decidual natural killer (dNK) cells resulted in increased secretion of IL-22, compared to culture of DSCs or dNK cells alone. The trophoblast cell line, HTR8/SVneo, expresses IL-22 receptor α1 (IL-22R1). Combinant human (rh) IL-22 significantly promoted the proliferation and viability, and inhibited the apoptosis of HTR8/SVneo cells. By Western blotting and immunohistochemistry, we confirmed that villi expressed IL-22R1, and the villi from unexplained spontaneous miscarriage patients expressed reduced levels of IL-22R1 than those from normal early pregnancy. These findings indicate that the IL-22 secreted by DSCs and dNK might promote the survival of trophoblasts and participate in the maintenance of pregnancy by binding to the IL-22R1. The reduced level of IL-22/IL-22R1 in villi might be involved in the occurrence of spontaneous miscarriage.
Indexed as
Identifiers
24040442PMC3759484W1731095772What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.