ArticleInternational journal of clinical and experimental pathology2013
AMPK activity is down-regulated in endothelial cells of GHS-R(-/-) mice.
Article in International journal of clinical and experimental pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Obesity-Induced PVAT Dysfunction and Atherosclerosis Development: The Role of GHSR-1a in Increased Macrophage Infiltration and Adipocytokine Secretion.Journal of cardiovascular development and disease · 2025Article
- N-Terminal Pro-Brain Natriuretic Peptide Correlates with Ghrelin and Acyl-Ghrelin in Pre-Dialysis Chronic Kidney Disease.International journal of molecular sciences · 2024Observational
- Effect of Ghrelin on the Cardiovascular System.Biology · 2022Review
- Research progress of ghrelin on cardiovascular disease.Bioscience reports · 2021Review
- Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease.Frontiers in neuroscience · 2020Review
- Anti-inflammatory Property of AMP-activated Protein Kinase.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2020Review
- Preliminary application of hybrid operation in the treatment of carotid artery stenosis in patients with complex ischemic cerebrovascular diseases.International journal of clinical and experimental pathology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ghrelin/GHS-R axis is known as its role in stimulating growth hormone release. Besides, it is also implicated in the regulation of atherosclerosis (AS), a chronic vascular disease that has been recognized as the main cause of coronary heart disease and cerebrovascular disease. It has been reported that both Ghrelin and AMPK play protective roles in AS by inhibiting the inflammatory response as well as cell proliferation. However, it remains unclear whether AMPK pathway is involved in Ghrelin/GHS-R-mediated inhibition of the inflammatory response and cell proliferation in AS. Here, we established the GHS-R gene knockout mice (GHS-R(-/-)) and found that AMPK activity is notably down-regulated in endothelial cells (ECs) of GHS-R(-/-) mice and the ECs from GHS-R(-/-) mice possess higher proliferative capability than the ECs from wild-type mice. Moreover, AMPK is activated in primary ECs upon Ghrelin induction in vitro. Taking together, the present study unravels that Ghrelin/GHS-R could efficiently activate AMPK in ECs, suggesting a possible mechanism that the roles of Ghrelin/GHS-R in the inhibition of inflammatory response and cell proliferation in AS disease may be partially mediated by activating AMPK.
Indexed as
Identifiers
24040441PMC3759483W127042025What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.