ArticlePloS one2013
Identification of an evolutionarily conserved cis-regulatory element controlling the Peg3 imprinted domain.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Determination of a New Biomarker at the Level of Gene Alteration in Cisplatin Ototoxicity.International journal of molecular sciences · 2025Article
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- Differentially methylated region in bovine MIMT1 detected by small-scale whole-genome methylation sequencing.Journal of applied genetics · 2019Article
- Article
- Intergenic and intronic DNA hypomethylated regions as putative regulators of imprinted domains.Epigenomics · 2018Article
- Allele and dosage specificity of the Peg3 imprinted domain.PloS one · 2018Article
- Transcription-driven DNA methylation setting on the mouse Peg3 locus.Epigenetics · 2017Article
- Parental and sexual conflicts over the Peg3 imprinted domain.Scientific reports · 2016Article
- Alternative promoters of Peg3 with maternal specificity.Scientific reports · 2016Article
- Sex and Tissue Specificity of Peg3 Promoters.PloS one · 2016Article
- Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain.PloS one · 2016Article
- Article
- Epigenetic instability of imprinted genes in human cancers.Nucleic acids research · 2015Article
- Bipartite structure of the inactive mouse X chromosome.Genome biology · 2015Article
- Epigenetic instability at imprinting control regions in a Kras(G12D)-induced T-cell neoplasm.Epigenetics · 2015Article
- Yy1 gene dosage effect and bi-allelic expression of Peg3.PloS one · 2015Article
- Regulation and function of the peg3 imprinted domain.Genomics & informatics · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian Peg3 domain harbors more than 20 evolutionarily conserved regions (ECRs) that are spread over the 250-kb genomic interval. The majority of these ECRs are marked with two histone modifications, H3K4me1 and H3K27ac, suggesting potential roles as distant regulatory elements for the transcription of the nearby imprinted genes. In the current study, the chromatin conformation capture (3C) method was utilized to detect potential interactions of these ECRs with the imprinted genes. According to the results, one region, ECR18, located 200-kb upstream of Peg3 interacts with the two promoter regions of Peg3 and Zim2. The observed interaction is most prominent in brain, but was also detected in testis. Histone modification and DNA methylation on ECR18 show no allele bias, implying that this region is likely functional on both alleles. In vitro assays also reveal ECR18 as a potential enhancer or repressor for the promoter of Peg3. Overall, these results indicate that the promoters of several imprinted genes in the Peg3 domain interact with one evolutionarily conserved region, ECR18, and further suggest that ECR18 may play key roles in the transcription and imprinting control of the Peg3 domain as a distant regulatory element.
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