ArticlePloS one2013
Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Clinical Trial of Salmon Nasal Cartilage-Derived Proteoglycans on Human Facial Antiaging: A Randomized, Double-Blind, Placebo-Controlled Study.Journal of cosmetic dermatology · 2025Trial
- Article
- Symphony of Digestion: Coordinated Host-Microbiome Enzymatic Interplay in Gut Ecosystem.Biomolecules · 2025Review
- Characterizing the human intestinal chondroitin sulfate glycosaminoglycan sulfation signature in inflammatory bowel disease.Scientific reports · 2024Article
- Effects of salmon cartilage proteoglycan on obesity in mice fed with a high-fat diet.Food science & nutrition · 2022Article
- Industrial application of fish cartilaginous tissues.Current research in food science · 2022Review
- Structural and Functional Alterations of Gut Microbiota in Males With Hyperuricemia and High Levels of Liver Enzymes.Frontiers in medicine · 2021Article
- Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern Hair Loss and Telogen Effluvium.Dermatology research and practice · 2020Review
- Oral delivery of pancreatitis-associated protein by Lactococcus lactis displays protective effects in dinitro-benzenesulfonic-acid-induced colitis model and is able to modulate the composition of the microbiota.Environmental microbiology · 2019Article
- Review
- Does Modification of the Large Intestinal Microbiome Contribute to the Anti-Inflammatory Activity of Fermentable Fiber?Current developments in nutrition · 2018Review
- A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity.Nature communications · 2017Article
- Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis.Biochemistry and biophysics reports · 2017Article
- Characterization of Proteoglycan and Hyaluronan in Hot Water Extract from Salmon Cartilage.Journal of applied glycoscience · 2017Article
- Attenuation of collagen-induced arthritis in mice by salmon proteoglycan.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteoglycan (PG) extracted from salmon nasal cartilage has potential to be a prophylactic agent. Daily oral administration of the PG attenuates systemic inflammatory response in the experimental mouse models. In this study, we applied the culture-independent approach to investigate an alteration of intestinal microbiota composition in PG-administered mice. The results indicated that the population level of bacilli increased in the small and large intestine upon PG administration. On the other hand, the population level of clostridia decreased in the large intestine. The proportion of bacteria that are able to ferment saccharides and produce short-chain fatty acids increased in the small intestine and decreased in the large intestine. Importantly, population level of probiotic lactobacilli and bacteria exhibiting the immunomodulatory effect increased in the PG-administered mice. In addition, several disease-associated bacteria decreased upon PG administration. These results provided an understanding of the specific role of PG involved in host immune modulation and supported our hypothesis that daily oral administration of PG improves the overall balance in composition of the intestinal microbial community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.