ArticlePloS one2013
Dietary restriction extends lifespan in wild-derived populations of Drosophila melanogaster.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The effect of dietary restriction on reproduction: a meta-analytic perspective.BMC evolutionary biology · 2016Pooled it
- Dietary restriction is evolutionarily conserved on the phenotypic and mechanistic level.EMBO reports · 2026Article
- Impact of Intermittent Fasting on Survival and Gene Expression Profiles Associated with Autophagy, Metabolism, and Antioxidant inACS omega · 2025Article
- Article
- Response of fruit fly (Physiological entomology · 2024Article
- The seesaw of diet restriction and lifespan: lessons from Drosophila studies.Biogerontology · 2021Article
- The relationship between longevity and diet is genotype dependent and sensitive to desiccation inThe Journal of experimental biology · 2020Article
- Review
- Review
- Evidence of dietary protein restriction regulating pupation height, development time and lifespan inBiology open · 2019Article
- Obesity May Accelerate the Aging Process.Frontiers in endocrinology · 2019Review
- Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature.Experimental gerontology · 2018Article
- Mitotype Interacts With Diet to Influence Longevity, Fitness, and Mitochondrial Functions in Adult FemaleFrontiers in genetics · 2018Article
- Bayesian association scan reveals loci associated with human lifespan and linked biomarkers.Nature communications · 2017Article
- Stage dependent nutritional regulation of transgenerational longevity.Nutrition and healthy aging · 2016Article
- LncRNA mediated regulation of aging pathways inAging · 2016Article
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.Proceedings. Biological sciences · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Dietary restriction (DR) can result in lifespan-extension and improved function and health during ageing. Although the impact of DR on lifespan and health has been established in a variety of organisms, most DR experiments are carried out on laboratory strains that have often undergone adaptation to laboratory conditions. The effect of DR on animals recently derived from wild populations is rarely assessed. We measured the DR response of four populations of Drosophila melanogaster within two generations of collection from the wild. All populations responded to DR with an increase in lifespan and a decrease in female fecundity, similarly to a control, laboratory-adapted strain. These effects of DR are thus not a result of adaptation to laboratory conditions, and reflect the characteristics of natural populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.