SynthesisPloS one2013
Neural correlates of psychotherapy in anxiety and depression: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prefrontal-limbic circuit modulation in anxiety disorders: Differential neural effects of psychotherapy versus pharmacotherapy revealed by ALE meta-analysis.Dialogues in clinical neuroscience · 2026Pooled it
- Comparing reappraisal and acceptance strategies to understand the neural architecture of emotion regulation: a meta-analytic approach.Frontiers in psychology · 2023Pooled it
- Neural correlates of psychodynamic and non-psychodynamic therapies in different clinical populations through fMRI: A meta-analysis and systematic review.Frontiers in human neuroscience · 2022Pooled it
- Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety.Neuroscience and biobehavioral reviews · 2018Pooled it
- A systematic review of the neural bases of psychotherapy for anxiety and related disorders.Dialogues in clinical neuroscience · 2015Pooled it
- Neuroimaging changes in major depression with brief computer-assisted cognitive behavioral therapy compared to waitlist.Molecular psychiatry · 2025Trial
- Habituation or Normalization? Experiential and Respiratory Recovery From Voluntary Hyperventilation in Treated Versus Untreated Patients With Panic Disorder.Behavior therapy · 2021Trial
- Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Trial
- Theranostic markers for personalized therapy of spider phobia: Methods of a bicentric external cross-validation machine learning approach.International journal of methods in psychiatric research · 2020Trial
- Cortical oxygenation during exposure therapy - in situ fNIRS measurements in arachnophobia.NeuroImage. Clinical · 2020Trial
- Selective Effects of Psychotherapy on Frontopolar Cortical Function in PTSD.The American journal of psychiatry · 2017Trial
- PTSD Psychotherapy Outcome Predicted by Brain Activation During Emotional Reactivity and Regulation.The American journal of psychiatry · 2017Trial
- Impact of cognitive-behavioral therapy for social anxiety disorder on the neural bases of emotional reactivity to and regulation of social evaluation.Behaviour research and therapy · 2014Trial
- Decoding acceptance and reappraisal strategies from resting state macro networks.Scientific reports · 2024Article
- Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change.Neural plasticity · 2024Review
- Article
- Role of Cognitive Control in Psychotherapy: An Integrated Review.Indian journal of psychological medicine · 2023Article
- Decoding reappraisal and suppression from neural circuits: A combined supervised and unsupervised machine learning approach.Cognitive, affective & behavioral neuroscience · 2023Article
- "Holding in Anger" as a Mediator in the Relationship between Attachment Orientations and Borderline Personality Features.Brain sciences · 2023Article
- Resting-state EEG delta and alpha power predict response to cognitive behavioral therapy in depression: a Canadian biomarker integration network for depression study.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have used neuroimaging methods to identify neural change in brain networks associated to emotion regulation after psychotherapy of depression and anxiety. In the present work we adopted a meta-analytic technique specific to neuroimaging data to evaluate the consistence of empirical findings and assess models of therapy that have been proposed in the literature. Meta-analyses were conducted with the Activation Likelihood Estimation technique, which evaluates the overlap between foci of activation across studies. The analysis included 16 studies found in Pubmed (200 foci of activation and 193 patients). Separate meta-analyses were conducted on studies of 1) depression, post-traumatic stress disorder and panic disorder investigated with rest state metabolism (6 studies, 70 patients); 2) depression, post-traumatic stress disorder and panic disorder investigated with task-related activation studies (5 studies, 65 patients); 3) the previous studies considered jointly; and 4) phobias investigated with studies on exposure-related activation (5 studies, 57 patients). Studies on anxiety and depression gave partially consistent results for changes in the dorsomedial prefrontal cortex and in the posterior cingulated gyrus/precuneus. Several areas of change in the temporal lobes were also observed. Studies on the therapy of phobia were consistent with a reduction of activity in medial temporal areas. The cluster of change in the prefrontal cortex may refer to increased recruitment of control processes, as hypothesized by influential models of emotion regulation changes due to psychotherapy. However, not all areas associated with controlled emotion regulation were detected in the meta-analysis, while involvement of midline structures suggested changes in self-related information processing. Changes in phobia were consistent with reduced reactivity to phobic stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.