ArticlePloS one2013
Myc-dependent genome instability and lifespan in Drosophila.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Conserved signaling pathways and transcriptional regulators drive ovarian aging across species.Poultry science · 2026Article
- The deubiquitinase USP36 funtions through catalytic-dependent and catalytic-independent mechanisms in Drosophila.Genetics · 2025Article
- Article
- Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies.Frontiers in aging neuroscience · 2025Review
- Protectin DX as a therapeutic strategy against frailty in mice.GeroScience · 2023Article
- MYC-an emerging player in mitochondrial diseases.Frontiers in cell and developmental biology · 2023Review
- Regulation of the somatotropic axis by MYC-mediated miRNA repression.Frontiers in cell and developmental biology · 2023Article
- Review
- Sirt6 regulates lifespan inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- RNA Polymerase III, Ageing and Longevity.Frontiers in genetics · 2021Review
- jouvence, a new human snoRNA involved in the control of cell proliferation.BMC genomics · 2020Article
- Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2.PLoS genetics · 2020Article
- Myc plays an important role in Drosophila P-M hybrid dysgenesis to eliminate germline cells with genetic damage.Communications biology · 2020Article
- Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila.Nature communications · 2020Article
- Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity.Cell reports · 2020Article
- Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance ineLife · 2019Article
- Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice.Journal of molecular endocrinology · 2019Article
- An ankyrin-binding motif regulates nuclear levels of L1-type neuroglian and expression of the oncogeneThe Journal of biological chemistry · 2018Article
- Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster.PLoS genetics · 2018Article
- Genomic Instabilities, Cellular Senescence, and Aging:Frontiers in medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The Myc family of transcription factors are key regulators of cell growth and proliferation that are dysregulated in a large number of human cancers. When overexpressed, Myc family proteins also cause genomic instability, a hallmark of both transformed and aging cells. Using an in vivo lacZ mutation reporter, we show that overexpression of Myc in Drosophila increases the frequency of large genome rearrangements associated with erroneous repair of DNA double-strand breaks (DSBs). In addition, we find that overexpression of Myc shortens adult lifespan and, conversely, that Myc haploinsufficiency reduces mutation load and extends lifespan. Our data provide the first evidence that Myc may act as a pro-aging factor, possibly through its ability to greatly increase genome instability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.