ArticlePloS one2013
Beneficial effects of wheat gluten hydrolysate to extend lifespan and induce stress resistance in nematode Caenorhabditis elegans.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies inACS omega · 2023Review
- The toxicity assessment of extract of Peganum harmala L. seeds in Caenorhabditis elegans.BMC complementary medicine and therapies · 2020Article
- Gliadin Intake Causes Disruption of the Intestinal Barrier and an Increase in Germ Cell Apoptosis in ANutrients · 2019Article
- Toxicity and multigenerational effects of bisphenol S exposure toToxicology research · 2019Article
- Graphene Oxide Dysregulates Neuroligin/NLG-1-Mediated Molecular Signaling in Interneurons in Caenorhabditis elegans.Scientific reports · 2017Article
- Adverse Effects of Hydroalcoholic Extracts and the Major Components in the Stems ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks.BMC systems biology · 2016Article
- Wnt Ligands Differentially Regulate Toxicity and Translocation of Graphene Oxide through Different Mechanisms in Caenorhabditis elegans.Scientific reports · 2016Article
- Metallothioneins act downstream of insulin signaling to regulate toxicity of outdoor fine particulate matter (PMToxicology research · 2016Article
- Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities.Oxidative medicine and cellular longevity · 2016Article
- The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans.Plant foods for human nutrition (Dordrecht, Netherlands) · 2014Article
- Full toxicity assessment of Genkwa Flos and the underlying mechanism in nematode Caenorhabditis elegans.PloS one · 2014Article
- Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans.Pharmacognosy magazineArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have showed that wheat gluten hydrolysate (WGH) has the anti-oxidative property. In the present study, we examined the possible safety property of WGH and the beneficial effects of WGH to extend lifespan and induce stress resistance using nematode Caenorhabditis elegans as the in vivo assay system. We found that WGH at concentrations of 0.1-1 mg/mL did not cause lethality, influence development, alter locomotion behavior and brood size, and induce significant intestinal autofluorescence and reactive oxygen species (ROS) production in young adults. Treatment with 0.1-1 mg/mL of WGH significantly extended lifespans of nematodes under the normal conditions. Moreover, WGH treatment significantly inhibited the induction of intestinal autofluorescence and suppressed the decrease in locomotion behavior during the aging process of nematodes. Furthermore, pre-treatment with 1 mg/mL of WGH significantly suppressed the adverse effects caused by heat-stress or oxidative stress on nematodes as indicated by the alterations of both lifespan and intestinal ROS production. Therefore, WGH treatment is relatively safe and has beneficial effects on nematodes under both the normal conditions and the stress conditions.
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