Trial reportPloS one2013
Reasons for non-completion of health related quality of life evaluations in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of objective and subjective quality of life among pediatric, adolescent, and young adult bone tumor survivors.Pediatric blood & cancer · 2015Pooled it
- Quality of life in pediatric acute myeloid leukemia: Report from the Children's Oncology Group.Cancer medicine · 2019Trial
- Children's Oncology Group 2023 blueprint: Nursing discipline.Pediatric blood & cancer · 2023Article
- Health-related quality of life predicts length of hospital stay and survival rates for pediatric patients receiving allogeneic hematopoietic cell transplantation.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Improving symptom control and reducing toxicities for pediatric patients with hematological malignancies.Hematology. American Society of Hematology. Education Program · 2020Review
- Randomized comparative study of child and caregiver responses to three software functions added to the Japanese version of the electronic Pediatric Quality of Life Inventory (ePedsQL) questionnaire.Journal of patient-reported outcomes · 2020Article
- Simple change in logistic procedure improves response rate to QOL assessment: a report from the Japan Children's Cancer Group.Journal of patient-reported outcomes · 2020Article
- Quality of Life of Patients With Osteosarcoma in the European American Osteosarcoma Study-1 (EURAMOS-1): Development and Implementation of a Questionnaire Substudy.JMIR research protocols · 2019Article
- Nurse-Led Programs to Facilitate Enrollment to Children's Oncology Group Cancer Control Trials.Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses · 2016Review
- Quality of Life in Children With Advanced Cancer: A Report From the PediQUEST Study.Journal of pain and symptom management · 2016Article
- Adolescent and Young Adult Patient Engagement and Participation in Survey-Based Research: A Report From the "Resilience in Adolescents and Young Adults With Cancer" Study.Pediatric blood & cancer · 2016Article
- Strategies to improve success of pediatric cancer cooperative group quality of life studies: a report from the Children's Oncology Group.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundHealth related quality of life (HRQL) assessments during therapy for pediatric cancer are important. The objective of this study was to describe reasons for failure to provide HRQL assessments during a pediatric acute myeloid leukemia (AML) clinical trial.
methodsWe focused on HRQL assessments embedded in a multicenter pediatric AML clinical trial. The PedsQL 4.0 Generic Core Scales, PedsQL 3.0 Acute Cancer Module, PedsQL Multidimensional Fatigue Scale, and Pediatric Inventory for Parents were obtained from parent/guardian respondents at a maximum of six time points. Children provided self-report optionally. A central study coordinator contacted sites with delinquent HRQL data. Reasons for failure to submit the HRQL assessments were evaluated by three pediatric oncologists and themes were generated using thematic analysis.
resultsThere were 906 completed and 1091 potential assessments included in this analysis (83%). The median age of included children was 12.9 years (range 2.0 to 18.9). The five themes for non-completion were: patient too ill; passive or active refusal by respondent; developmental delay; logistical challenges; and poor knowledge of study processes from both the respondent and institutional perspective.
conclusionsWe identified reasons for non-completion of HRQL assessments during active therapy. This information will facilitate recommendations to improve study processes and future HRQL study designs to maximize response rates.
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