ArticlePloS one2013
In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Brain-derived uroguanylin as a regulator of postprandial brown adipose tissue activation: a potential therapeutic approach for metabolic disorders.Frontiers in pharmacology · 2025Article
- Xenon-enhanced computed tomography assessment of brown adipose tissue distribution and perfusion in lean, obese, and diabetic primates.Obesity (Silver Spring, Md.) · 2022Article
- Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors.Annals of the New York Academy of Sciences · 2021Review
- Stat5a promotes brown adipocyte differentiation and thermogenic program through binding and transactivating the Kdm6a promoter.Cell cycle (Georgetown, Tex.) · 2020Article
- Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.Pflugers Archiv : European journal of physiology · 2020Article
- Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.Frontiers in endocrinology · 2020Review
- MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold.Journal of the Endocrine Society · 2019Article
- Distinguishing Lipid Subtypes by Amplifying Contrast from J-Coupling.Scientific reports · 2019Article
- Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: AnFrontiers in endocrinology · 2019Article
- Mapping brown adipose tissue based on fat water fraction provided by Z-spectral imaging.Journal of magnetic resonance imaging : JMRI · 2018Article
- Correlation distance dependence of the resonance frequency of intermolecular zero quantum coherences and its implication for MR thermometry.Magnetic resonance in medicine · 2018Article
- Non-invasive methods for the assessment of brown adipose tissue in humans.The Journal of physiology · 2018Review
- Accurate quantification of brown adipose tissue mass by xenon-enhanced computed tomography.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Non-invasive Imaging Methods for Brown Adipose Tissue Detection and Function Evaluation.Internal medicine: open access · 2018Article
- A pilot study on the correlation between fat fraction values and glucose uptake values in supraclavicular fat by simultaneous PET/MRI.Magnetic resonance in medicine · 2017Article
- Automated segmentation of human cervical-supraclavicular adipose tissue in magnetic resonance images.Scientific reports · 2017Article
- Remote detection of hyperpolarizedThe Journal of chemical physics · 2016Article
- Imaging of Brown Adipose Tissue: State of the Art.Radiology · 2016Review
- Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry.Magnetic resonance in medicine · 2016Article
- PreclinicalFrontiers in pharmacology · 2016Review
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Authors and funding
8 authors.
Funding
Abstract
The recent discovery of active Brown Adipose Tissue (BAT) in adult humans has opened new avenues for obesity research and treatment, as reduced BAT activity seem to be implicated in human energy imbalance, diabetes, and hypertension. However, clinical applications are currently limited by the lack of non-invasive tools for measuring mass and function of this tissue in humans. Here we present a new magnetic resonance imaging method based on the normally invisible intermolecular multiple-quantum coherence (1)H MR signal. This method, which doesn't require special hardware modifications, can be used to overcome partial volume effect, the major limitation of MR-based approaches that are currently being investigated for the detection of BAT in humans. With this method we can exploit the characteristic cellular structure of BAT to selectively image it, even when (as in humans) it is intimately mixed with other tissues. We demonstrate and validate this method in mice using PET scans and histology. We compare this methodology with conventional (1)H MR fat fraction methods. Finally, we investigate its feasibility for the detection of BAT in humans.
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