ArticlePloS one2013
Gymnemic acids inhibit hyphal growth and virulence in Candida albicans.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
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- Eicosapentaenoic acid influences the pathogenesis of Candida albicans in Caenorhabditis elegans via inhibition of hyphal formation and stimulation of the host immune response.Medical microbiology and immunology · 2023Article
- 3-Hydroxy coumarin demonstrates anti-biofilm and anti-hyphal efficacy against Candida albicans via inhibition of cell-adhesion, morphogenesis, and virulent genes regulation.Scientific reports · 2023Article
- Inhibitory Effects of the Fungal Pigment Rubiginosin C on Hyphal and Biofilm Formation inJournal of fungi (Basel, Switzerland) · 2023Article
- Vaginal Infections' Etiologies in South-Eastern Gabon - An Overview.International journal of women's health · 2022Article
- Inhibition ofFrontiers in cellular and infection microbiology · 2022Article
- The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases.Frontiers in cellular and infection microbiology · 2022Review
- Cell Surface Expression of Nrg1 Protein inJournal of fungi (Basel, Switzerland) · 2021Article
- Anticapsular and Antifungal Activity of α-Cyperone.Antibiotics (Basel, Switzerland) · 2021Article
- Can Leaves and Stems ofPharmaceuticals (Basel, Switzerland) · 2020Article
- Separation of Bioactive Small Molecules, Peptides from Natural Sources and Proteins from Microbes by Preparative Isoelectric Focusing (IEF) Method.Journal of visualized experiments : JoVE · 2020Article
- Efficacy of Chelerythrine Against Mono- and Dual-Species Biofilms of Candida albicans and Staphylococcus aureus and Its Properties of Inducing Hypha-to-Yeast Transition of C. albicans.Journal of fungi (Basel, Switzerland) · 2020Article
- Broad-spectrum antifungal activities and mechanism of drimane sesquiterpenoids.Microbial cell (Graz, Austria) · 2020Article
- Piperine Impedes Biofilm Formation and Hyphal Morphogenesis ofFrontiers in microbiology · 2020Article
- Simple Carbohydrate Derivatives Diminish the Formation of Biofilm of the Pathogenic YeastAntibiotics (Basel, Switzerland) · 2019Article
- MRI and fluorescence studies of Saccharomyces cerevisiae loaded with a bimodal Fe(III) TJournal of inorganic biochemistry · 2019Article
- Probiotic Yeasts Inhibit Virulence of NonmBio · 2019Article
- Gymnemic Acids Inhibit Adhesive Nanofibrillar MediatedFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Candida albicans is an opportunistic and polymorphic fungal pathogen that causes mucosal, disseminated and invasive infections in humans. Transition from the yeast form to the hyphal form is one of the key virulence factors in C. albicans contributing to macrophage evasion, tissue invasion and biofilm formation. Nontoxic small molecules that inhibit C. albicans yeast-to-hypha conversion and hyphal growth could represent a valuable source for understanding pathogenic fungal morphogenesis, identifying drug targets and serving as templates for the development of novel antifungal agents. Here, we have identified the triterpenoid saponin family of gymnemic acids (GAs) as inhibitor of C. albicans morphogenesis. GAs were isolated and purified from Gymnema sylvestre leaves, the Ayurvedic traditional medicinal plant used to treat diabetes. Purified GAs had no effect on the growth and viability of C. albicans yeast cells but inhibited its yeast-to-hypha conversion under several hypha-inducing conditions, including the presence of serum. Moreover, GAs promoted the conversion of C. albicans hyphae into yeast cells under hypha inducing conditions. They also inhibited conidial germination and hyphal growth of Aspergillus sp. Finally, GAs inhibited the formation of invasive hyphae from C. albicans-infected Caenorhabditis elegans worms and rescued them from killing by C. albicans. Hence, GAs could be useful for various antifungal applications due to their traditional use in herbal medicine.
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