ArticlePloS one2013
Mitochondrial haplotypes associated with biomarkers for Alzheimer's disease.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.PLoS genetics · 2014Pooled it
- Mitochondrial DNA and Alzheimer's disease: a first case-control study of the Tunisian population.Molecular biology reports · 2022Article
- The Other Side of Alzheimer's Disease: Influence of Metabolic Disorder Features for Novel Diagnostic Biomarkers.Journal of personalized medicine · 2020Review
- Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Mitonuclear interactions influence Alzheimer's disease risk.Neurobiology of aging · 2020Article
- Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.Cell death & disease · 2018Review
- Review
- Mitochondria and Alzheimer's Disease: the Role of Mitochondrial Genetic Variation.Current genetic medicine reports · 2018Review
- Asiaticoside ameliorates β-amyloid-induced learning and memory deficits in rats by inhibiting mitochondrial apoptosis and reducing inflammatory factors.Experimental and therapeutic medicine · 2017Article
- Mitochondria, Cybrids, Aging, and Alzheimer's Disease.Progress in molecular biology and translational science · 2017Review
- Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism.Oxidative medicine and cellular longevity · 2017Article
- Triad of Risk for Late Onset Alzheimer's: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex.Frontiers in aging neuroscience · 2016Review
- Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer's disease neurodegeneration.Frontiers in aging neuroscience · 2015Article
- Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease.BMC genomics · 2014Article
- Is Alzheimer's disease a systemic disease?Biochimica et biophysica acta · 2014Review
- The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.Biochimica et biophysica acta · 2014Review
- The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease.Human genetics · 2014Review
- Alzheimer disease: Variations in mitochondrial DNA predict AD-related brain atrophy.Nature reviews. Neurology · 2013Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Various studies have suggested that the mitochondrial genome plays a role in late-onset Alzheimer's disease, although results are mixed. We used an endophenotype-based approach to further characterize mitochondrial genetic variation and its relationship to risk markers for Alzheimer's disease. We analyzed longitudinal data from non-demented, mild cognitive impairment, and late-onset Alzheimer's disease participants in the Alzheimer's Disease Neuroimaging Initiative with genetic, brain imaging, and behavioral data. We assessed the relationship of structural MRI and cognitive biomarkers with mitochondrial genome variation using TreeScanning, a haplotype-based approach that concentrates statistical power by analyzing evolutionarily meaningful groups (or clades) of haplotypes together for association with a phenotype. Four clades were associated with three different endophenotypes: whole brain volume, percent change in temporal pole thickness, and left hippocampal atrophy over two years. This is the first study of its kind to identify mitochondrial variation associated with brain imaging endophenotypes of Alzheimer's disease. Our results provide additional evidence that the mitochondrial genome plays a role in risk for Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.