ArticlePloS one2013
Elevated serum iron is a potent biomarker for spirometric resistance to cigarette smoke among Japanese males: the Takahata study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Effect of hyperhomocysteinemia on a murine model of smoke-induced pulmonary emphysema.Scientific reports · 2022Article
- Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane.Oncology letters · 2021Article
- Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.Scientific reports · 2020Observational
- To "Fe"ed or Not to "Fe"ed: Iron Depletion Exacerbates Emphysema Development in Murine Smoke Model.American journal of respiratory cell and molecular biology · 2020Article
- Smoking-induced iron dysregulation in the lung.Free radical biology & medicine · 2019Review
- The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2017Article
- Indices of iron homeostasis correlate with airway obstruction in an NHANES III cohort.International journal of chronic obstructive pulmonary disease · 2017Article
- Associations between Lifestyle Factors and Iron Overload in Korean Adults.Clinical nutrition research · 2016Article
- Article
- Association between plasma adiponectin levels and decline in forced expiratory volume in 1 s in a general Japanese population: the Takahata study.International journal of medical sciences · 2014Article
- Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis.International journal of chronic obstructive pulmonary diseaseReview
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic obstructive pulmonary disease is a common disability among elderly subjects with a heavy cigarette smoking habit. In contrast to the population that is susceptible to smoking, in whom pulmonary function worsens with the length of exposure to cigarette smoke, there are elderly individuals whose pulmonary function is not impaired. However, to date, the characteristics of this resistant smoking population have not been investigated. We aimed to identify a biomarker in individuals in whom lung health is maintained despite smoking. Blood sampling and spirometry were performed on 3,257 subjects who participated in a community-based annual health check in Takahata, Japan, from 2004 to 2006. We selected 117 elderly smokers (age ≥70, Brinkman index ≥600, smoking years ≥30). The 'smoking resistant' group met the following criteria: FEV1/FVC ≥0.7, and FEV1%predicted ≥80. Spirometry was re-evaluated in 147 male, current smokers in 2009. Baseline serum iron (sFe) levels were higher in the smoke resistant group compared with the non-resistant group. In those with low sFe levels, FEV1/FVC was reduced in male subjects. These spirometric measures were positively associated with sFe levels in men. Multiple linear regression analysis revealed that sFe levels were predictive for spirometric values, independent of other clinical factors. In addition, sFe levels were predictive for a decline in FEV1.Serum iron levels may be a biomarker for the spirometric susceptibility of individuals to cigarette smoke.
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