ArticlePloS one2013
Sex-related differences of cortical thickness in patients with chronic abdominal pain.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 82 citations in OpenAlex.
- Imaging findings of irritable bowel syndrome patients, and the diagnostic value of irritable bowel syndrome: A systematic review.World journal of methodology · 2025Article
- Sex-based associations between neighborhood disadvantage and brain-gut alterations in individuals with irritable bowel syndrome.Biology of sex differences · 2025Article
- Neuroplasticity of the white matter tracts underlying recovery of diarrhea-predominant irritable bowel syndrome following acupuncture treatment.Frontiers in neuroscience · 2024Article
- Cognition of abdominal pain and abdominal discomfort in Chinese patients with irritable bowel syndrome with diarrhea.BioPsychoSocial medicine · 2023Article
- The impact of gender medicine on neonatology: the disadvantage of being male: a narrative review.Italian journal of pediatrics · 2023Review
- The neurobiology of irritable bowel syndrome.Molecular psychiatry · 2023Review
- A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits.Neuropharmacology · 2023Review
- Research hotspots and trends in visceral pain research: A global comprehensive bibliometric analysis.Frontiers in molecular neuroscience · 2022Article
- Irritable bowel syndrome in women: Association between decreased insular subregion volumes and gastrointestinal symptoms.NeuroImage. Clinical · 2022Article
- The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder.Nutrients · 2021Review
- A Resting-state Functional Magnetic Resonance Imaging Study of Whole-brain Functional Connectivity of Voxel Levels in Patients With Irritable Bowel Syndrome With Depressive Symptoms.Journal of neurogastroenterology and motility · 2021Article
- Association between pain sensitivity and gray matter properties in the sensorimotor network in women with irritable bowel syndrome.Neurogastroenterology and motility · 2021Article
- Sex- and Gender-Related Differences in Common Functional Gastroenterologic Disorders.Mayo Clinic proceedings · 2021Review
- Aberrant Intraregional Brain Activity and Functional Connectivity in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.Frontiers in neuroscience · 2021Article
- Detection of microstructural white matter alterations in functional gastrointestinal disorders assessed by diffusion kurtosis imaging.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults.Journal of pain research · 2020Article
- Review
- Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility · 2018Review
- Disease-Related Microstructural Differences in the Brain in Women With Provoked Vestibulodynia.The journal of pain · 2018Article
- White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsRegional reductions in gray matter (GM) have been reported in several chronic somatic and visceral pain conditions, including irritable bowel syndrome (IBS) and chronic pancreatitis. Reported GM reductions include insular and anterior cingulate cortices, even though subregions are generally not specified. The majority of published studies suffer from limited sample size, heterogeneity of populations, and lack of analyses for sex differences. We aimed to characterize regional changes in cortical thickness (CT) in a large number of well phenotyped IBS patients, taking into account the role of sex related differences.
methodsCortical GM thickness was determined in 266 subjects (90 IBS [70 predominantly premenopausal female] and 176 healthy controls (HC) [155 predominantly premenopausal female]) using the Laboratory of Neuro Imaging (LONI) Pipeline. A combined region of interest (ROI) and whole brain approach was used to detect any sub-regional and vertex-level differences after removing effects of age and total GM volume. Correlation analyses were performed on behavioral data.
resultsWhile IBS as a group did not show significant differences in CT compared to HCs, sex related differences were observed both within the IBS and the HC groups. When female IBS patients were compared to female HCs, whole brain analysis showed significant CT increase in somatosensory and primary motor cortex, as well as CT decrease in bilateral subgenual anterior cingulate cortex (sgACC). The ROI analysis showed significant regional CT decrease in bilateral subregions of insular cortex, while CT decrease in cingulate was limited to left sgACC, accounting for the effect of age and GM volume. Several measures of IBS symptom severity showed significant correlation with CT changes in female IBS patients.
conclusionsSignificant, sex related differences in CT are present in both HCs and in IBS patients. The biphasic neuroplastic changes in female IBS patients are related to symptom severity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.