ArticlePloS one2013
Proteolytic pathways induced by herbicides that inhibit amino acid biosynthesis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 68 citations in OpenAlex.
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- Effects of the novel HPPD-inhibitor herbicide QYM201 on enzyme activity and microorganisms, and its degradation in soil.Ecotoxicology (London, England) · 2021Article
- Physiological Approach to the Use of the Natural Compound Quinate in the Control of Sensitive and ResistantPlants (Basel, Switzerland) · 2020Article
- Hypoxic Treatment Decreases the Physiological Action of the Herbicide Imazamox onPlants (Basel, Switzerland) · 2020Article
- Transcriptome Analysis Identifies Candidate Target Genes Involved in Glyphosate-Resistance Mechanism inPlants (Basel, Switzerland) · 2020Article
- Dipteryx alata, a tree native to the Brazilian Cerrado, is sensitive to the herbicide nicosulfuron.Ecotoxicology (London, England) · 2020Article
- Physiological performance of glyphosate and imazamox mixtures on Amaranthus palmeri sensitive and resistant to glyphosate.Scientific reports · 2019Article
- ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides.Journal of experimental botany · 2019Article
- Effects of EPSPS Copy Number Variation (CNV) and Glyphosate Application on the Aromatic and Branched Chain Amino Acid Synthesis Pathways inFrontiers in plant science · 2017Article
- Effects of the novel cis-nitromethylene neonicotinoid insecticide Paichongding on enzyme activities and microorganisms in yellow loam and Huangshi soils.Environmental science and pollution research international · 2016Article
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- Subfamily-Specific Fluorescent Probes for Cysteine Proteases Display Dynamic Protease Activities during Seed Germination.Plant physiology · 2015Article
- Effects of the novel pyrimidynyloxybenzoic herbicide ZJ0273 on enzyme activities, microorganisms and its degradation in Chinese soils.Environmental science and pollution research international · 2015Article
- RNA-Seq analysis of rye-grass transcriptomic response to an herbicide inhibiting acetolactate-synthase identifies transcripts linked to non-target-site-based resistance.Plant molecular biology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe herbicides glyphosate (Gly) and imazamox (Imx) inhibit the biosynthesis of aromatic and branched-chain amino acids, respectively. Although these herbicides inhibit different pathways, they have been reported to show several common physiological effects in their modes of action, such as increasing free amino acid contents and decreasing soluble protein contents. To investigate proteolytic activities upon treatment with Gly and Imx, pea plants grown in hydroponic culture were treated with Imx or Gly, and the proteolytic profile of the roots was evaluated through fluorogenic kinetic assays and activity-based protein profiling.
resultsSeveral common changes in proteolytic activity were detected following Gly and Imx treatment. Both herbicides induced the ubiquitin-26 S proteasome system and papain-like cysteine proteases. In contrast, the activities of vacuolar processing enzymes, cysteine proteases and metacaspase 9 were reduced following treatment with both herbicides. Moreover, the activities of several putative serine protease were similarly increased or decreased following treatment with both herbicides. In contrast, an increase in YVADase activity was observed under Imx treatment versus a decrease under Gly treatment.
conclusionThese results suggest that several proteolytic pathways are responsible for protein degradation upon herbicide treatment, although the specific role of each proteolytic activity remains to be determined.
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