ArticlePloS one2013
Previous exposure to an RNA virus does not protect against subsequent infection in Drosophila melanogaster.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Current insights into insect immune memory.eLife · 2025Review
- Infection risk by oral contamination does not induce immune priming in the mealworm beetle (Frontiers in immunology · 2024Article
- Viruses in LaboratoryViruses · 2023Article
- Heterogeneities in infection outcomes across species: sex and tissue differences in virus susceptibility.Peer community journal · 2023Article
- Context-Dependent Viral Transgenerational Immune Priming in Honey Bees (Hymenoptera: Apidae).Journal of insect science (Online) · 2022Article
- Review
- Host Resistance to Bacterial Infection Varies Over Time, but Is Not Affected by a Previous Exposure to the Same Pathogen.Frontiers in physiology · 2022Article
- Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios.Journal of evolutionary biology · 2021Article
- Article
- A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance.The Journal of animal ecology · 2019Article
- Immune priming and clearance of orally acquired RNA viruses in Drosophila.Nature microbiology · 2018Article
- Defense Mechanisms against Viral Infection inViruses · 2018Review
- Host shifts result in parallel genetic changes when viruses evolve in closely related species.PLoS pathogens · 2018Article
- Review
- Pre-exposure to non-pathogenic bacteria does not protect Drosophila against the entomopathogenic bacterium Photorhabdus.PloS one · 2018Article
- Symbiont strain is the main determinant of variation in Wolbachia-mediated protection against viruses across Drosophila species.Molecular ecology · 2017Article
- Complex Coding and Regulatory Polymorphisms in a Restriction Factor Determine the Susceptibility ofGenetics · 2017Article
- Innate and intrinsic antiviral immunity in Drosophila.Cellular and molecular life sciences : CMLS · 2017Review
- Article
- Addicted? Reduced host resistance in populations with defensive symbionts.Proceedings. Biological sciences · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundImmune priming has been shown to occur in a wide array of invertebrate taxa, with individuals exposed to a pathogen showing increased protection upon subsequent exposure. However, the mechanisms underlying immune priming are poorly understood. The antiviral RNAi response in Drosophila melanogaster is an ideal candidate for providing a specific and acquired response to subsequent infection. We exposed D. melanogaster to two challenges of a virus known to produce an antiviral RNAi response, to examine whether any protective effects of prior exposure on survival were observed.
resultsIn this experiment we found no evidence that prior exposure to Drosophila C Virus (DCV) protects flies from a subsequent lethal challenge, with almost identical levels of mortality in flies previously exposed to DCV or a control.
conclusionsOur results confirm the finding that 'acquired' immune responses are not ubiquitous across all invertebrate-pathogen interactions. We discuss why we may have observed no effect in this study, with focus on the mechanistic basis of the RNAi pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.