ArticlePloS one2013
Stability of the acetic acid-induced bladder irritation model in alpha chloralose-anesthetized female cats.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Alpha-chloralose poisoning in 25 cats: clinical picture and evaluation of treatment with intravenous lipid emulsion.Journal of feline medicine and surgery · 2024Article
- Real-time prediction of bladder urine leakage using fuzzy inference system and dual Kalman filtering in cats.Scientific reports · 2024Article
- Alpha-chloralose poisoning in cats: clinical findings in 25 confirmed and 78 suspected cases.Journal of feline medicine and surgery · 2022Article
- Alpha-chloralose poisoning in cats in three Nordic countries - the importance of secondary poisoning.BMC veterinary research · 2022Article
- Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning.Journal of analytical toxicology · 2022Article
- Closed-loop sacral neuromodulation for bladder function using dorsal root ganglia sensory feedback in an anesthetized feline model.Medical & biological engineering & computing · 2022Article
- Stimulation of the pelvic nerve increases bladder capacity in the PGEAmerican journal of physiology. Renal physiology · 2020Article
- Real-Time Bladder Pressure Estimation for Closed-Loop Control in a Detrusor Overactivity Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2019Article
- Behavioral Monitoring and Neuromodulation of Feline Voiding Function.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2019Article
- Role of neurogenic inflammation in local communication in the visceral mucosa.Seminars in immunopathology · 2018Review
- Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis.Frontiers in systems neuroscience · 2018Article
- Lumbosacral spinal segmental contributions to tibial and pudendal neuromodulation of bladder overactivity in cats.Neurourology and urodynamics · 2017Article
- Sex difference in the contribution of GABAAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Neurotransmitter Mechanisms Underlying Sacral Neuromodulation of Bladder Overactivity in Cats.Neuromodulation : journal of the International Neuromodulation Society · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time- and vehicle-related variability of bladder and urethral rhabdosphincter (URS) activity as well as cardiorespiratory and blood chemistry values were examined in the acetic acid-induced bladder irritation model in α-chloralose-anesthetized female cats. Additionally, bladder and urethra were evaluated histologically using Mason trichrome and toluidine blue staining. Urodynamic, cardiovascular and respiratory parameters were collected during intravesical saline infusion followed by acetic acid (0.5%) to irritate the bladder. One hour after starting acetic acid infusion, a protocol consisting of a cystometrogram, continuous infusion-induced rhythmic voiding contractions, and a 5 min "quiet period" (bladder emptied without infusion) was precisely repeated every 30 minutes. Administration of vehicle (saline i.v.) occurred 15 minutes after starting each of the first 7 cystometrograms and duloxetine (1mg/kg i.v.) after the 8(th). Acetic acid infusion into the bladder increased URS-EMG activity, bladder contraction frequency, and decreased contraction amplitude and capacity, compared to saline. Bladder activity and URS activity stabilized within 1 and 2 hours, respectively. Duloxetine administration significantly decreased bladder contraction frequency and increased URS-EMG activity to levels similar to previous reports. Cardiorespiratory parameters and blood gas levels remained consistent throughout the experiment. The epithelium of the bladder and urethra were greatly damaged and edema and infiltration of neutrophils in the lamina propria of urethra were observed. These data provide an ample evaluation of the health of the animals, stability of voiding function and appropriateness of the model for testing drugs designed to evaluate lower urinary tract as well as cardiovascular and respiratory systems function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.