ArticlePloS one2013
Geometry-driven cell organization determines tissue growths in scaffold pores: consequences for fibronectin organization.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.Bioactive materials · 2026Article
- Multilayer dual-porosity 3D printed scaffolds to recreate the anisotropic microenvironment of the hyaline cartilage.Materials today. Bio · 2025Article
- The combinatory effect of scaffold topography and culture condition: an approach to nucleus pulposus tissue engineering.Future science OA · 2022Article
- Definition, measurement, and function of pore structure dimensions of bioengineered porous bone tissue materials based on additive manufacturing: A review.Frontiers in bioengineering and biotechnology · 2022Review
- Preliminary clinical results of coated porous tibia cones in septic and aseptic revision knee arthroplasty.Archives of orthopaedic and trauma surgery · 2021Article
- A Review on Design and Mechanical Properties of Additively Manufactured NiTi Implants for Orthopedic Applications.International journal of bioprinting · 2021Review
- Human trabecular meshwork cell behavior is influenced by collagen scaffold pore architecture and glycosaminoglycan composition.Biotechnology and bioengineering · 2020Article
- Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance.Frontiers in bioengineering and biotechnology · 2020Article
- Integrated Design Approaches for 3D Printed Tissue Scaffolds: Review and Outlook.Materials (Basel, Switzerland) · 2019Review
- Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Methods for producing microstructured hydrogels for targeted applications in biology.Acta biomaterialia · 2019Review
- Direct Ink Write (DIW) 3D Printed Cellulose Nanocrystal Aerogel Structures.Scientific reports · 2017Article
- Surface Curvature Differentially Regulates Stem Cell Migration and Differentiation via Altered Attachment Morphology and Nuclear Deformation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Computationally designed lattices with tuned properties for tissue engineering using 3D printing.PloS one · 2017Article
- Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials.Advanced materials (Deerfield Beach, Fla.) · 2016Review
- The Effect of Gradations in Mineral Content, Matrix Alignment, and Applied Strain on Human Mesenchymal Stem Cell Morphology within Collagen Biomaterials.Advanced healthcare materials · 2016Article
- Gradual conversion of cellular stress patterns into pre-stressed matrix architecture during in vitro tissue growth.Journal of the Royal Society, Interface · 2016Article
- Controlling Cell Functions and Fate with Surfaces and Hydrogels: The Role of Material Features in Cell Adhesion and Signal Transduction.Gels (Basel, Switzerland) · 2016Review
- Hierarchical polymeric scaffolds support the growth of MC3T3-E1 cells.Journal of materials science. Materials in medicine · 2015Article
- Silk Fibroin-Based Scaffold for Bone Tissue Engineering.Advances in experimental medicine and biologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To heal tissue defects, cells have to bridge gaps and generate new extracellular matrix (ECM). Macroporous scaffolds are frequently used to support the process of defect filling and thus foster tissue regeneration. Such biomaterials contain micro-voids (pores) that the cells fill with their own ECM over time. There is only limited knowledge on how pore geometry influences cell organization and matrix production, even though it is highly relevant for scaffold design. This study hypothesized that 1) a simple geometric description predicts cellular organization during pore filling at the cell level and that 2) pore closure results in a reorganization of ECM. Scaffolds with a broad distribution of pore sizes (macroporous starPEG-heparin cryogel) were used as a model system and seeded with primary fibroblasts. The strategies of cells to fill pores could be explained by a simple geometrical model considering cells as tensioned chords. The model matched qualitatively as well as quantitatively by means of cell number vs. open cross-sectional area for all pore sizes. The correlation between ECM location and cell position was higher when the pores were not filled with tissue (Pearson's coefficient ρ = 0.45±0.01) and reduced once the pores were closed (ρ = 0.26±0.04) indicating a reorganization of the cell/ECM network. Scaffold pore size directed the time required for pore closure and furthermore impacted the organization of the fibronectin matrix. Understanding how cells fill micro-voids will help to design biomaterial scaffolds that support the endogenous healing process and thus allow a fast filling of tissue defects.
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