ArticlePloS one2013
Stochastic stabilization of phenotypic States: the genetic bistable switch as a case study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms.Development (Cambridge, England) · 2025Review
- Systematic analysis and optimization of early warning signals for critical transitions using distribution data.iScience · 2023Article
- Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs.PLoS computational biology · 2021Article
- Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch.Molecular systems biology · 2020Article
- Measurement-induced dynamics and stabilization of spinor-condensate domain walls.Physical review. A · 2019Article
- Bistability and Nonmonotonic Induction of the lac Operon in the Natural Lactose Uptake System.Biophysical journal · 2017Article
- Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in theeLife · 2017Article
- Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches.PLoS computational biology · 2016Article
- Gene switching rate determines response to extrinsic perturbations in the self-activation transcriptional network motif.Scientific reports · 2016Article
- The cellular Ising model: a framework for phase transitions in multicellular environments.Journal of the Royal Society, Interface · 2016Article
- The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions.The Journal of chemical physics · 2015Article
- Modeling the epigenetic attractors landscape: toward a post-genomic mechanistic understanding of development.Frontiers in genetics · 2015Review
- Noise in multiple sclerosis: unwanted and necessary.Annals of clinical and translational neurology · 2014Article
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2 authors.
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Abstract
We study by means of analytical calculation and stochastic simulations how intrinsic noise modifies the bifurcation diagram of gene regulatory processes that can be effectively described by the Langevin formalism. In a general context, our study raises the intriguing question of how biochemical fluctuations redesign the epigenetic landscape in differentiation processes. We have applied our findings to a general class of regulatory processes that includes the simplest case that displays a bistable behavior and hence phenotypic variability: the genetic auto-activating switch. Thus, we explain why and how the noise promotes the stability of the low-state phenotype of the switch and show that the bistable region is extended when increasing the intensity of the fluctuations. This phenomenology is found in a simple one-dimensional model of the genetic switch as well as in a more detailed model that takes into account the binding of the protein to the promoter region. Altogether, we prescribe the analytical means to understand and quantify the noise-induced modifications of the bifurcation points for a general class of regulatory processes where the genetic bistable switch is included.
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