ArticlePloS one2013
Topographical body fat distribution links to amino acid and lipid metabolism in healthy obese women [corrected].
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Associations of childhood BMI, general and visceral fat mass with metabolite profiles at school-age.International journal of obesity (2005) · 2024Article
- Article
- The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men.Scientific reports · 2023Article
- Dietary intake of branched-chain amino acids in relation to general and abdominal obesity.Eating and weight disorders : EWD · 2022Article
- Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue.American journal of epidemiology · 2022Article
- Metabolomic signatures for visceral adiposity and dysglycaemia in Asian Chinese and Caucasian European adults: the cross-sectional TOFI_Asia study.Nutrition & metabolism · 2020Article
- Integration of whole-body [Scientific reports · 2020Observational
- Reproducibility of semiautomated body composition segmentation of abdominal computed tomography: a multiobserver study.European radiology experimental · 2019Article
- Metabolomics: a search for biomarkers of visceral fat and liver fat content.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity.Environment international · 2019Article
- Gene-Environment Interactions on Body Fat Distribution.International journal of molecular sciences · 2019Review
- Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study.Journal of the American Heart Association · 2019Article
- The Relationship between Eicosanoid Levels and Serum Levels of Metabolic and Hormonal Parameters Depending on the Presence of Metabolic Syndrome in Patients with Benign Prostatic Hyperplasia.International journal of environmental research and public health · 2019Article
- The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology.Metabolites · 2018Review
- Plasma-free amino acid profiles are predictors of cancer and diabetes development.Nutrition & diabetes · 2017Review
- Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites.PloS one · 2017Article
- Associations of anthropometric markers with serum metabolites using a targeted metabolomics approach: results of the EPIC-potsdam study.Nutrition & diabetes · 2016Article
- NMR-based metabolomics highlights differences in plasma metabolites in pigs exhibiting diet-induced differences in adiposity.European journal of nutrition · 2016Article
- Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice.PloS one · 2016Article
- Lipidomics to Assess Omega 3 Bioactivity.Journal of clinical medicine · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Visceral adiposity is increasingly recognized as a key condition for the development of obesity related disorders, with the ratio between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) reported as the best correlate of cardiometabolic risk. In this study, using a cohort of 40 obese females (age: 25-45 y, BMI: 28-40 kg/m(2)) under healthy clinical conditions and monitored over a 2 weeks period we examined the relationships between different body composition parameters, estimates of visceral adiposity and blood/urine metabolic profiles. Metabonomics and lipidomics analysis of blood plasma and urine were employed in combination with in vivo quantitation of body composition and abdominal fat distribution using iDXA and computerized tomography. Of the various visceral fat estimates, VAT/SAT and VAT/total abdominal fat ratios exhibited significant associations with regio-specific body lean and fat composition. The integration of these visceral fat estimates with metabolic profiles of blood and urine described a distinct amino acid, diacyl and ether phospholipid phenotype in women with higher visceral fat. Metabolites important in predicting visceral fat adiposity as assessed by Random forest analysis highlighted 7 most robust markers, including tyrosine, glutamine, PC-O 44∶6, PC-O 44∶4, PC-O 42∶4, PC-O 40∶4, and PC-O 40∶3 lipid species. Unexpectedly, the visceral fat associated inflammatory profiles were shown to be highly influenced by inter-days and between-subject variations. Nevertheless, the visceral fat associated amino acid and lipid signature is proposed to be further validated for future patient stratification and cardiometabolic health diagnostics.
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