ArticlePloS one2013
In vitro infection of pupae with Israeli acute paralysis virus suggests disturbance of transcriptional homeostasis in honey bees (Apis mellifera).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 81 citations in OpenAlex.
- Viruses and vectors tied to honey bee colony losses.PLoS pathogens · 2026Article
- Injection but not ingestion of a mixed virus suspension in Queensland fruit fly (Bactrocera tryoni) shifts persistent covert infection to acute pathology.Pest management science · 2026Article
- Interactions of husbandry, landscape, and immunity in regulating viral loads for managed honey bees.Biology open · 2025Article
- Israeli Acute Paralysis Virus Is an Emerging Pathogen Contributing to Brood Disease ofViruses · 2024Article
- Plants and Their Derivatives as Promising Therapeutics for Sustainable Control of Honeybee (Pathogens (Basel, Switzerland) · 2023Review
- Potassium ion channels as a molecular target to reduce virus infection and mortality of honey bee colonies.Virology journal · 2023Article
- Consequences of microsporidian prior exposure for virus infection outcomes and bumble bee host health.Oecologia · 2023Article
- Effects of planted pollinator habitat on pathogen prevalence and interspecific detection between bee species.Scientific reports · 2022Article
- Honey Bee Genetic Stock Determines Deformed Wing Virus Symptom Severity but not Viral Load or Dissemination Following Pupal Exposure.Frontiers in genetics · 2022Article
- Context-Dependent Viral Transgenerational Immune Priming in Honey Bees (Hymenoptera: Apidae).Journal of insect science (Online) · 2022Article
- IAPV-Induced Paralytic Symptoms Associated with Tachypnea via Impaired Tracheal System Function.International journal of molecular sciences · 2021Article
- Identities, concentrations, and sources of pesticide exposure in pollen collected by managed bees during blueberry pollination.Scientific reports · 2021Article
- A SNP assay for assessing diversity in immune genes in the honey bee (Apis mellifera L.).Scientific reports · 2021Article
- Article
- Reproductive activation in honeybee (Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Comparing Survival of Israeli Acute Paralysis Virus Infection among Stocks of U.S. Honey Bees.Insects · 2021Article
- Host Genotype and Tissue Type Determine DWV Infection Intensity.Frontiers in insect science · 2021Article
- Impact of Sacbrood Virus on Larval Microbiome ofInsects · 2020Article
- Pesticide-Virus Interactions in Honey Bees: Challenges and Opportunities for Understanding Drivers of Bee Declines.Viruses · 2020Review
- A Reverse Genetics System for the Israeli Acute Paralysis Virus and Chronic Bee Paralysis Virus.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ongoing decline of honey bee health worldwide is a serious economic and ecological concern. One major contributor to the decline are pathogens, including several honey bee viruses. However, information is limited on the biology of bee viruses and molecular interactions with their hosts. An experimental protocol to test these systems was developed, using injections of Israeli Acute Paralysis Virus (IAPV) into honey bee pupae reared ex-situ under laboratory conditions. The infected pupae developed pronounced but variable patterns of disease. Symptoms varied from complete cessation of development with no visual evidence of disease to rapid darkening of a part or the entire body. Considerable differences in IAPV titer dynamics were observed, suggesting significant variation in resistance to IAPV among and possibly within honey bee colonies. Thus, selective breeding for virus resistance should be possible. Gene expression analyses of three separate experiments suggest IAPV disruption of transcriptional homeostasis of several fundamental cellular functions, including an up-regulation of the ribosomal biogenesis pathway. These results provide first insights into the mechanisms of IAPV pathogenicity. They mirror a transcriptional survey of honey bees afflicted with Colony Collapse Disorder and thus support the hypothesis that viruses play a critical role in declining honey bee health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.