ArticlePloS one2013
Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Circ_DLG1 facilitates cell proliferation and metastasis of esophageal squamous cell carcinoma via upregulating MAP3K9.Esophagus : official journal of the Japan Esophageal Society · 2025Article
- miR-195b is required for proper cellular homeostasis in the elderly.Scientific reports · 2024Article
- Single-cell Transcriptomes Reveal Characteristics of MicroRNAs in Gene Expression Noise Reduction.Genomics, proteomics & bioinformatics · 2021Article
- miRNA interplay: mechanisms and consequences in cancer.Disease models & mechanisms · 2021Review
- Article
- Transcriptomic Analysis Reveals Cu/Zn SODs Acting as Hub Genes of SODs inAntioxidants (Basel, Switzerland) · 2020Article
- Low levels of tumour suppressor miR-655 in plasma contribute to lymphatic progression and poor outcomes in oesophageal squamous cell carcinoma.Molecular cancer · 2019Article
- A Novel Model for Predicting Associations between Diseases and LncRNA-miRNA Pairs Based on a Newly Constructed Bipartite Network.Computational and mathematical methods in medicine · 2018Article
- Cross disease analysis of co-functional microRNA pairs on a reconstructed network of disease-gene-microRNA tripartite.BMC bioinformatics · 2017Article
- miRsig: a consensus-based network inference methodology to identify pan-cancer miRNA-miRNA interaction signatures.Scientific reports · 2017Article
- Identification of More Feasible MicroRNA-mRNA Interactions within Multiple Cancers Using Principal Component Analysis Based Unsupervised Feature Extraction.International journal of molecular sciences · 2016Article
- Anticancer bioactive peptide-3 inhibits human gastric cancer growth by targeting miR-338-5p.Cell & bioscience · 2016Article
- Reconstruction of temporal activity of microRNAs from gene expression data in breast cancer cell line.BMC genomics · 2015Article
- Detecting key genes regulated by miRNAs in dysfunctional crosstalk pathway of myasthenia gravis.BioMed research international · 2015Article
- Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.Scientific reports · 2014Article
- Exploration of potential roles of a new LOXL2 splicing variant using network knowledge in esophageal squamous cell carcinoma.TheScientificWorldJournal · 2014Article
- PPI network analysis of mRNA expression profile of ezrin knockdown in esophageal squamous cell carcinoma.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationships between miRNAs and their regulatory influences in esophageal carcinoma remain largely unknown. Accumulated evidence suggests that delineation of subpathways within an entire pathway can underlie complex diseases. To analyze the regulation of differentially expressed miRNAs in subpathways of esophageal squamous cell carcinoma (ESCC), we constructed bipartite miRNA and subpathway networks to determine miRNA regulatory influences on subpathways. The miRNA-subpathway network indicated that miRNAs regulate numerous subpathways. Two principal biological networks were derived from the miRNA-subpathway network by the hypergeometric test. This miRNA-miRNA network revealed the co-regulation of subpathways between the upregulated and downregulated miRNAs. Subpathway-subpathway networks characterized scale free, small world, and modular architecture. K-clique analysis revealed co-regulation of subpathways between certain downregulated and upregulated miRNAs. When ESCC patients were grouped according to their expression levels of paired upregulation of miR-31 and downregulation of miR-338-3p, survival time analysis revealed a significant difference based on miR-31-miR-338-3p interaction. These findings can facilitate the understanding of the biological meaning of miRNA-miRNA interactions with either the same or opposite expression trend.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.