ArticlePLoS genetics2013
Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 81 citations in OpenAlex.
- Anesthetic action on the transmission delay between cortex and thalamus explains the beta-buzz observed under propofol anesthesia.PloS one · 2017Trial
- Modulatory mechanism of the paraventricular thalamus (PVT) under general anesthesia.Frontiers in pharmacology · 2026Review
- Reanimation of rodents: an animal model for cognitive recovery from anaesthesia.British journal of anaesthesia · 2025Article
- A probabilistic model of behavioural emergence from general anaesthesia in mice.British journal of anaesthesia · 2025Article
- Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep in humans.Nature communications · 2024Article
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
- Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep.bioRxiv : the preprint server for biology · 2024Article
- Re-examining the role of the dorsal fan-shaped body in promoting sleep in Drosophila.Current biology : CB · 2023Article
- Modulation and neural correlates of postmating sleep plasticity in Drosophila females.Current biology : CB · 2023Article
- Explosive Synchronization-Based Brain Modulation Reduces Hypersensitivity in the Brain Network: A Computational Model Study.Frontiers in computational neuroscience · 2022Article
- A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79.G3 (Bethesda, Md.) · 2021Article
- Article
- The 2020 Pittendrigh/Aschoff Lecture: My Circadian Journey.Journal of biological rhythms · 2021Article
- Explaining anaesthetic hysteresis with effect-site equilibration.British journal of anaesthesia · 2021Article
- Electroencephalographic Evidence for Individual Neural Inertia in Mice That Decreases With Time.Frontiers in systems neuroscience · 2021Article
- The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.Frontiers in neuroscience · 2021Article
- Resistance to state transitions in responsiveness is differentially modulated by different volatile anaesthetics in male mice.British journal of anaesthesia · 2020Article
- Neural Inertia: A Sticky Situation for Anesthesia.Journal of neurosurgical anesthesiology · 2020Article
- Perioperative Neurocognitive Disorder: State of the Preclinical Science.Anesthesiology · 2020Review
- Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia.eLife · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
A robust, bistable switch regulates the fluctuations between wakefulness and natural sleep as well as those between wakefulness and anesthetic-induced unresponsiveness. We previously provided experimental evidence for the existence of a behavioral barrier to transitions between these states of arousal, which we call neural inertia. Here we show that neural inertia is controlled by processes that contribute to sleep homeostasis and requires four genes involved in electrical excitability: Sh, sss, na and unc79. Although loss of function mutations in these genes can increase or decrease sensitivity to anesthesia induction, surprisingly, they all collapse neural inertia. These effects are genetically selective: neural inertia is not perturbed by loss-of-function mutations in all genes required for the sleep/wake cycle. These effects are also anatomically selective: sss acts in different neurons to influence arousal-promoting and arousal-suppressing processes underlying neural inertia. Supporting the idea that anesthesia and sleep share some, but not all, genetic and anatomical arousal-regulating pathways, we demonstrate that increasing homeostatic sleep drive widens the neural inertial barrier. We propose that processes selectively contributing to sleep homeostasis and neural inertia may be impaired in pathophysiological conditions such as coma and persistent vegetative states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.