ArticleNew journal of physics2013
Modeling of nanotherapeutics delivery based on tumor perfusion.
Article in New journal of physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- The Role of Optical Imaging in Translational Nanomedicine.Journal of functional biomaterials · 2022Review
- Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis.Frontiers in bioengineering and biotechnology · 2020Review
- Improving nanotherapy delivery and action through image-guided systems pharmacology.Theranostics · 2020Review
- Pharmacokinetic/Pharmacodynamics Modeling of Drug-Loaded PLGA Nanoparticles Targeting Heterogeneously Vascularized Tumor Tissue.Pharmaceutical research · 2019Article
- Efficacy of Surface-Modified PLGA Nanoparticles as a Function of Cervical Cancer Type.Pharmaceutical research · 2019Article
- Evaluation of Drug-Loaded Gold Nanoparticle Cytotoxicity as a Function of Tumor Vasculature-Induced Tissue Heterogeneity.Annals of biomedical engineering · 2019Article
- Design Optimization of Tumor Vasculature-Bound Nanoparticles.Scientific reports · 2018Article
- Targeting Ligand Specificity Linked to Tumor Tissue Topological Heterogeneity via Single-Cell Micro-Pharmacological Modeling.Scientific reports · 2018Article
- Nanoparticle-mediated drug delivery to treat infections in the female reproductive tract: evaluation of experimental systems and the potential for mathematical modeling.International journal of nanomedicine · 2018Review
- Development of Halofluorochromic Polymer Nanoassemblies for the Potential Detection of Liver Metastatic Colorectal Cancer Tumors Using Experimental and Computational Approaches.Pharmaceutical research · 2017Article
- Distribution of PLGA-modified nanoparticles in 3D cell culture models of hypo-vascularized tumor tissue.Journal of nanobiotechnology · 2017Article
- Molecular Imaging in Nanotechnology and Theranostics.Molecular imaging and biology · 2017Review
- Enhanced uptake and transport of PLGA-modified nanoparticles in cervical cancer.Journal of nanobiotechnology · 2016Article
- The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction.Nanomedicine (London, England) · 2016Review
- Cell source determines the immunological impact of biomimetic nanoparticles.Biomaterials · 2016Article
- An interdisciplinary computational/experimental approach to evaluate drug-loaded gold nanoparticle tumor cytotoxicity.Nanomedicine (London, England) · 2016Article
- Evaluation of uptake and distribution of gold nanoparticles in solid tumors.European physical journal plus · 2015Article
- Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles.PloS one · 2015Article
- Intravital Microscopy Imaging Approaches for Image-Guided Drug Delivery Systems.Current drug targets · 2015Review
- Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Heterogeneities in the perfusion of solid tumors prevent optimal delivery of nanotherapeutics. Clinical imaging protocols to obtain patient-specific data have proven difficult to implement. It is challenging to determine which perfusion features hold greater prognostic value and to relate measurements to vessel structure and function. With the advent of systemically administered nanotherapeutics, whose delivery is dependent on overcoming diffusive and convective barriers to transport, such knowledge is increasingly important. We describe a framework for the automated evaluation of vascular perfusion curves measured at the single vessel level. Primary tumor fragments, collected from triple-negative breast cancer patients and grown as xenografts in mice, were injected with fluorescence contrast and monitored using intravital microscopy. The time to arterial peak and venous delay, two features whose probability distributions were measured directly from time-series curves, were analyzed using a Fuzzy C-mean (FCM) supervised classifier in order to rank individual tumors according to their perfusion characteristics. The resulting rankings correlated inversely with experimental nanoparticle accumulation measurements, enabling modeling of nanotherapeutics delivery without requiring any underlying assumptions about tissue structure or function, or heterogeneities contained within. With additional calibration, these methodologies may enable the study of nanotherapeutics delivery strategies in a variety of tumor models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.