ArticleThe Korean journal of parasitology2013
Superoxide anion production by human neutrophils activated by Trichomonas vaginalis.
Article in The Korean journal of parasitology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Neutrophil reactive oxygen species response to Trichomonas vaginalis modulated by palmitic acid.Parasites, hosts and diseases · 2026Article
- IDO1 promotes Echinococcus multilocularis infection by regulating the formation of neutrophil extracellular traps.Veterinary research · 2025Article
- Infinity war:Microbial cell (Graz, Austria) · 2023Review
- Trichomonas vaginalis triggers neutrophil extracellular traps reducing parasite integrity and growth.Parasitology research · 2022Article
- Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-Haematologica · 2019Article
- The state of art of neutrophil extracellular traps in protozoan and helminthic infections.Bioscience reports · 2019Review
- Adenosine reduces reactive oxygen species and interleukin-8 production by Trichomonas vaginalis-stimulated neutrophils.Purinergic signalling · 2017Article
- Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis.Parasites & vectors · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils are the predominant inflammatory cells found in vaginal discharges of patients infected with Trichomonas vaginalis. In this study, we examined superoxide anion (O2 (.-)) production by neutrophils activated by T. vaginalis. Human neutrophils produced superoxide anions when stimulated with either a lysate of T. vaginalis, its membrane component (MC), or excretory-secretory product (ESP). To assess the role of trichomonad protease in production of superoxide anions by neutrophils, T. vaginalis lysate, ESP, and MC were each pretreated with a protease inhibitor cocktail before incubation with neutrophils. Superoxide anion production was significantly decreased by this treatment. Trichomonad growth was inhibited by preincubation with supernatants of neutrophils incubated for 3 hr with T. vaginalis lysate. Furthermore, myeloperoxidase (MPO) production by neutrophils was stimulated by live trichomonads. These results indicate that the production of superoxide anions and MPO by neutrophils stimulated with T. vaginalis may be a part of defense mechanisms of neutrophils in trichomoniasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.