ArticleInternational forum of allergy & rhinology2013
Epidermal growth factor receptor, p16, cyclin D1, and p53 staining patterns for inverted papilloma.
Article in International forum of allergy & rhinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association of human papillomavirus infection and epidermal growth factor receptor mutations in inverted sinonasal papilloma: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- Inverted Sinonasal Papilloma: Pheno-endotyping and Predictive Markers of Recurrence and Malignancy - A Systematic Review.Current allergy and asthma reports · 2026Pooled it
- Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Pooled it
- Epithelial Markers in Sinonasal Inverted Papilloma with Malignant Transformation: A Scoping Review and Proposal for an Integrative Model of Malignant Risk Stratification.Diagnostics (Basel, Switzerland) · 2026Review
- Assessment of TP53 and CDKN2A status as predictive markers of malignant transformation of sinonasal inverted papilloma.Scientific reports · 2024Article
- Factors Associated with Dysplastic Changes in Sinonasal Inverted Papilloma: Study of Tumor Infiltrating Lymphocytes (TILs) FOXP3, CD4, CD8, and expression of p53.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Article
- IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma.Analytical cellular pathology (Amsterdam) · 2021Article
- Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing.International journal of clinical oncology · 2018Article
- Advances in recurrence and malignant transformation of sinonasal inverted papillomas.Oncology letters · 2017Article
- Risk Factors of Recurrence and Malignant Transformation of Sinonasal Inverted Papilloma.BioMed research international · 2017Review
- Human papillomavirus infection and biomarkers in sinonasal inverted papillomas: clinical significance and molecular mechanisms.International forum of allergy & rhinology · 2015Article
- Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16(INK4a) in sinonasal diseases.Infectious agents and cancer · 2015Article
- Sinonasal mass lesions: A clinicopathological study with p63 and p16 immunohistochemical expressions.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe aim of this study was better characterize the staining patterns of inverted papilloma (IP) with and without carcinoma by performing immunohistochemistry for p16, epidermal growth factor receptor (EGFR), p53, and cyclin D1 antibodies in a large patient cohort.
methodsA total of 162 IP specimens were collected from 147 patients treated at the University of Michigan between 1996 and 2011. Twenty-two specimens contained carcinoma. Tumor was extracted for construction of 2 tissue microarrays and stained for p16, EGFR, p53, and cyclin D1. Tumor staining intensity and percentage staining were scored.
resultsBenign disease was positive for p16 in 64%, EGFR in 50%, p53 in 30%, and cyclin D1 in 76%. IP with carcinomatous degeneration was positive for p16 in 14%, EGFR in 71%, p53 in 62%, and cyclin D1 in 76%. The differences in staining positivity between benign and malignant disease reached significance for p16 and p53 only. Mean percentage staining by tumor surface area for IP and IP with carcinoma was 12% vs 7% for p16 (no statistical significance [NS]), 20% vs 34% for EGFR (NS), 4% vs 24% for p53 (p < 0.001), and 17% vs 21% for cyclin D1 (NS).
conclusionImportant characteristic staining pattern for IP with and without carcinoma are highlighted in this study. Unlike recent trends in human papilloma virus (HPV)-related head and neck malignancies, low expression of p16 is a marker for malignancy in this series. Positive staining for p53 correlates with the development of carcinoma in IP.
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