ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2013
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Current Advances in the Physiological Roles and Disease-Associated Mechanisms of ADAMTS16.International journal of molecular sciences · 2026Review
- Convergent Lower Expression of Redox-Linked Stress-Adaptation and Synaptic-Plasticity Genes in Major Depressive Disorder Across Seven Postmortem dlPFC Cohorts.Antioxidants (Basel, Switzerland) · 2026Article
- Role of ADAMTS16 metalloproteinase in pathogenesis of cryptorchidism.Archives of medical science : AMS · 2026Article
- Abnormal O-glycan sialylation in the mPFC contributes to depressive-like behaviors in male mice.Science advances · 2025Article
- Genetic overlap between functional impairment and depression and anxiety symptom severity: evidence from the GLAD Study.Psychological medicine · 2025Article
- Advances in discerning the mechanisms underlying depression and resiliency: relation to the neurobiology of stress and the effects of antidepressants.Molecular psychiatry · 2025Review
- A German translation and validation of the sense of agency scale.Frontiers in psychology · 2023Article
- Resilience in severe mental disorders: correlations to clinical measures and quality of life in hospitalized patients with major depression, bipolar disorder, and schizophrenia.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Chondroitin Sulphate Proteoglycan Axonal Coats in the Human Mediodorsal Thalamic Nucleus.Frontiers in integrative neuroscience · 2022Article
- A comprehensive model of predictors of quality of life in older adults with schizophrenia: results from the CSA study.Social psychiatry and psychiatric epidemiology · 2021Article
- Review
- Molecular signature of extracellular matrix pathology in schizophrenia.The European journal of neuroscience · 2021Article
- Study of Functional Impairment in Students of Elementary and Secondary Public Schools in Iran.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2021Article
- Associations between the development of PTSD symptoms and longitudinal changes in the DNA methylome of deployed military servicemen: A comparison with polygenic risk scores.Comprehensive psychoneuroendocrinology · 2020Article
- Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study.European archives of psychiatry and clinical neuroscience · 2020Article
- Using World Health Organization Disability Assessment Schedule 2.0 in people with schizophrenia: a 4-year follow-up.European archives of psychiatry and clinical neuroscience · 2020Article
- The genetics of bipolar disorder.Molecular psychiatry · 2020Review
- Genomics and psychological resilience: a research agenda.Molecular psychiatry · 2019Review
- Shared preventive factors associated with relapse after a response to electroconvulsive therapy in four major psychiatric disorders.Psychiatry and clinical neurosciences · 2019Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Functional impairment is one of the most enduring, intractable consequences of psychiatric disorders and is both familial and heritable. Previous studies have suggested that variation in functional impairment can be independent of symptom severity. Here we report the first genome-wide association study (GWAS) of functional impairment in the context of major mental illness. Participants of European-American descent (N = 2,246) were included from three large treatment studies of bipolar disorder (STEP-BD) (N = 765), major depressive disorder (STAR*D) (N = 1091), and schizophrenia (CATIE) (N = 390). At study entry, participants completed the SF-12, a widely used measure of health-related quality of life. We performed a GWAS and pathway analysis of the mental and physical components of health-related quality of life across diagnosis (∼1.6 million single nucleotide polymorphisms), adjusting for psychiatric symptom severity. Psychiatric symptom severity was a significant predictor of functional impairment, but it accounted for less than one-third of the variance across disorders. After controlling for diagnostic category and symptom severity, the strongest evidence of genetic association was between variants in ADAMTS16 and physical functioning (P = 5.87 × 10(-8) ). Pathway analysis did not indicate significant enrichment after correction for gene clustering and multiple testing. This study illustrates a phenotypic framework for examining genetic contributions to functional impairment across psychiatric disorders.
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