Trial reportJournal of biomedical materials research. Part B, Applied biomaterials2013
Effects of sterilization treatments on bulk and surface properties of nanocomposite biomaterials.
Trial report in Journal of biomedical materials research. Part B, Applied biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- Sulfonated polyether ketone ketone (SPEKK) implant as an alternative to titanium implant-in vivo study on Wistar Albino rat mandible.BMC oral health · 2025Article
- Small-Caliber Vascular Grafts Engineered from Decellularized Leaves and Cross-Linked Gelatin.Tissue engineering. Part A · 2023Article
- Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalentsBiomaterials and biosystems · 2022Article
- Autoclaving pHEMA-Based Hydrogels Immersed in Deionized Water has No Effect on Physicochemical Properties and Cell Behaviors.ACS omega · 2022Article
- Biobased Elastomer Nanofibers Guide Light-Controlled Human-iPSC-Derived Skeletal Myofibers.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Recent Advances in Polyurethane/POSS Hybrids for Biomedical Applications.Molecules (Basel, Switzerland) · 2021Review
- Understanding Surface Modifications Induced via Argon Plasma Treatment through Secondary Electron Hyperspectral Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Effect of UV and Gamma Irradiation Sterilization Processes in the Properties of Different Polymeric Nanoparticles for Biomedical Applications.Materials (Basel, Switzerland) · 2020Article
- Acemannan increased bone surface, bone volume, and bone density in a calvarial defect model in skeletally-mature rats.Journal of dental sciences · 2018Article
- Sustained Release Drug Delivery Applications of Polyurethanes.Pharmaceutics · 2018Review
- Evaluation of three different decontamination techniques on biofilm formation, and on physical and chemical properties of resin composites.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
- Effects of different sterilization methods on surface characteristics and biofilm formation on zirconia in vitro.Dental materials : official publication of the Academy of Dental Materials · 2018Article
- Evaluation of Sterilisation Techniques for Regenerative Medicine Scaffolds Fabricated with Polyurethane Nonbiodegradable and Bioabsorbable Nanocomposite Materials.International journal of biomaterials · 2018Article
- The Effect of Sterilization Methods on the Structural and Chemical Properties of Fibrin Microthread Scaffolds.Macromolecular bioscience · 2016Article
- Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.Biomaterials · 2016Article
- Controllable degradation kinetics of POSS nanoparticle-integrated poly(ε-caprolactone urea)urethane elastomers for tissue engineering applications.Scientific reports · 2015Article
- Improved Sterilization of Sensitive Biomaterials with Supercritical Carbon Dioxide at Low Temperature.PloS one · 2015Article
- Short stimulation of electro-responsive PAA/fibrin hydrogel induces collagen production.Tissue engineering. Part C, Methods · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the continuous and expanding use of implantable biomaterials in a clinical setting, this study aims to elucidate the influence of sterilization techniques on the material surface and bulk properties of two polyurethane nanocomposite biomaterials. Both solid samples and porous membranes of nondegradable polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) and a biodegradable poly(caprolactone-urea) urethane (POSS-PCL) were examined. Sterilization techniques included conventional steam sterilization (autoclaving), gamma irradiation, and disinfection via incubating with ethanol (EtOH) for 10 min or 24 h. After treatment, the samples were examined using gel permeation chromatography (GPC), attenuated total reflectance Fourier transform infrared spectroscopy, and tensiometry. Cytotoxicity was evaluated through the culture of endothelial progenitor cells and the efficacy of sterilization method was determined by incubating each sample in tryptone soya broth and fluid thioglycollate medium for cultivation of microorganisms. Although EtOH did not affect the material properties in any form, the samples were found to be nonsterile with microbial growth detected on each of the samples. Gamma irradiation was not only effective in sterilizing both POSS-PCU and POSS-PCL but also led to minor material degradation and displayed a cytotoxic effect on the cultured cells. Autoclaving was found to be the optimal sterilization technique for both solid and porous membranes of the nondegradable POSS-PCU samples as it was successful in sterilizing the samples, displayed no cytotoxic side effects and did not degrade the material. However, the biodegradable POSS-PCL was not able to withstand the harsh environment during autoclaving, resulting in it losing all structural integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.