ArticlePediatric blood & cancer2014
PedsQL™ Multidimensional Fatigue Scale in sickle cell disease: feasibility, reliability, and validity.
Article in Pediatric blood & cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06012825 (Pediatric Physical Activity), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pediatric Physical Activity (PePA): Understanding Best Practices in Implementing Physical Activity for Patients Diagnosed With Childhood Cancer
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Measurement of fatigue in sickle cell disease: a systematic review of fatigue measures.Orphanet journal of rare diseases · 2025Pooled it
- Systematic literature review and assessment of patient-reported outcome instruments in sickle cell disease.Health and quality of life outcomes · 2018Pooled it
- Appraisal of patient-reported outcome measures in analogous diseases and recommendations for use in phase II and III clinical trials of pyruvate kinase deficiency.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Trial
- A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children.Blood · 2015Trial
- Health-related quality of life after allogeneic hematopoietic stem cell transplantation for sickle cell disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2015Trial
- Assessing and categorizing health-related quality of life outcomes in children and youth with acquired brain injury in outpatient rehabilitation.Journal of pediatric rehabilitation medicine · 2026Article
- Interdisciplinary Pediatric Long-COVID Care: A Descriptive Study of Interventions and Health-Related Quality of Life.Open forum infectious diseases · 2026Article
- Fatigue in Inactive Auto-Inflammatory Diseases and Opportunities for Optimizing Clinical Care: A Single-Center Observational Study.Journal of clinical medicine · 2025Article
- Pain, sleep, fatigue, and health-related quality of life in pediatric sickle cell disease: a serial multiple mediator analysis.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- A cross-sectional analysis of air pollution in primary schools and children fatigue.Frontiers in public health · 2025Article
- Development and Initial Validation of a Frailty Score for Pediatric Patients with Congenital and Acquired Heart Disease.Pediatric cardiology · 2024Article
- Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study.Health and quality of life outcomes · 2024Article
- Fatigue among children and adolescents with acquired brain injury in a specialized neurorehabilitation setting.Frontiers in rehabilitation sciences · 2024Article
- Examining the influence of pain and fatigue on neurocognitive functioning in adolescents and young adults with sickle cell disease.Pediatric blood & cancer · 2023Article
- Fatigue, Stress Appraisal, and Emotional Functioning Among Youth With Sickle Cell Disease: A Daily Diary Study.Journal of pediatric psychology · 2023Article
- Article
- Research knowledge transfer to improve the care and support of adolescents with sickle cell disease in Ghana.Health expectations : an international journal of public participation in health care and health policy · 2022Article
- Fatigue and Quality of Life in Children with Chronic Kidney Disease.Children (Basel, Switzerland) · 2022Article
- Prevalence and Impact of Fatigue in Children with Primary Immunodeficiency Disorders: a Quantitative Single-Center Study.Journal of clinical immunology · 2022Observational
- Trajectories, Risk Factors, and Impact of Persistent Pain After Major Musculoskeletal Surgery in Adolescents: A Replication Study.The journal of pain · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundSickle cell disease (SCD) is an inherited blood disorder characterized by a chronic hemolytic anemia that can contribute to fatigue and global cognitive impairment in patients. The study objective was to report on the feasibility, reliability, and validity of the PedsQL™ Multidimensional Fatigue Scale in SCD for pediatric patient self-report ages 5-18 years and parent proxy-report for ages 2-18 years. PROCEDURE: This was a cross-sectional multi-site study whereby 240 pediatric patients with SCD and 303 parents completed the 18-item PedsQL™ Multidimensional Fatigue Scale. Participants also completed the PedsQL™ 4.0 Generic Core Scales.
resultsThe PedsQL™ Multidimensional Fatigue Scale evidenced excellent feasibility, excellent reliability for the Total Scale Scores (patient self-report α = 0.90; parent proxy-report α = 0.95), and acceptable reliability for the three individual scales (patient self-report α = 0.77-0.84; parent proxy-report α = 0.90-0.97). Intercorrelations of the PedsQL™ Multidimensional Fatigue Scale with the PedsQL™ Generic Core Scales were predominantly in the large (≥0.50) range, supporting construct validity. PedsQL™ Multidimensional Fatigue Scale Scores were significantly worse with large effects sizes (≥0.80) for patients with SCD than for a comparison sample of healthy children, supporting known-groups discriminant validity. Confirmatory factor analysis demonstrated an acceptable to excellent model fit in SCD.
conclusionsThe PedsQL™ Multidimensional Fatigue Scale demonstrated acceptable to excellent measurement properties in SCD. The results demonstrate the relative severity of fatigue symptoms in pediatric patients with SCD, indicating the potential clinical utility of multidimensional assessment of fatigue in patients with SCD in clinical research and practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.