ArticlePharmaceutical statistics
A practical guide to Bayesian group sequential designs.
Article in Pharmaceutical statistics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04466670 (Dynamics of Hemostatic Parameters in COVID-19 and Comparison of Intervention Strategies Through Adaptive Clinical Trial), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dynamics of Hemostatic Parameters in COVID-19 and Comparison of Intervention Strategies Through Adaptive Clinical Trial
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bayesian Approaches for Confirmatory Trials in Rare Diseases: Opportunities and Challenges.International journal of environmental research and public health · 2021Pooled it
- Near real-time vaccine safety surveillance using electronic health records-a systematic review of the application of statistical methods.Pharmacoepidemiology and drug safety · 2016Pooled it
- A Randomized Pilot Trial of Micronutrient Supplementation for Under-5 Children in an Urban Low-Cost Flat Community in Malaysia: A Framework for Community-Based Research Integration.International journal of environmental research and public health · 2022Trial
- Six-Month Outcomes from the NEXit Junior Trial of a Text Messaging Smoking Cessation Intervention for High School Students: Randomized Controlled Trial With Bayesian Analysis.JMIR mHealth and uHealth · 2021Trial
- Cost-Effectiveness of Transcranial Magnetic Stimulation and Virtual Reality-Based Cognitive Remediation for Depressive Symptoms among Cancer Patients: Protocol for a Three-Arm Randomized Controlled Trial.Clinical practice and epidemiology in mental health : CP & EMH · 2026Article
- An efficient single-arm Bayesian adaptive trial algorithm to evaluate de-intensified oncologic treatment.Trials · 2025Article
- Article
- Monitoring overall survival in pivotal trials in indolent cancers.Statistics in biopharmaceutical research · 2025Article
- Reporting and communication of sample size calculations in adaptive clinical trials: a review of trial protocols and grant applications.BMC medical research methodology · 2024Review
- Using Bayesian statistics in confirmatory clinical trials in the regulatory setting: a tutorial review.BMC medical research methodology · 2024Review
- Systemic therapies in hepatocellular carcinoma: A revolution?United European gastroenterology journal · 2024Review
- Applications of the prediction of satisfaction design for monitoring single-arm phase II trials.PloS one · 2024Article
- Avoiding Under- and Overrecruitment in Behavioral Intervention Trials Using Bayesian Sequential Designs: Tutorial.Journal of medical Internet research · 2022Article
- Digital multiple health behaviour change intervention targeting online help seekers: protocol for the COACH randomised factorial trial.BMJ open · 2022Article
- Adaptive treatment allocation and selection in multi-arm clinical trials: a Bayesian perspective.BMC medical research methodology · 2022Article
- Effects of a waiting list control design on alcohol consumption among online help-seekers: protocol for a randomised controlled trial.BMJ open · 2021Article
- The Bayesian Design of Adaptive Clinical Trials.International journal of environmental research and public health · 2021Review
- BayesCTDesign: An R Package for Bayesian Trial Design Using Historical Control Data.Journal of statistical software · 2021Article
- Effects of a Text Messaging Smoking Cessation Intervention Among Online Help Seekers and Primary Health Care Visitors in Sweden: Protocol for a Randomized Controlled Trial Using a Bayesian Group Sequential Design.JMIR research protocols · 2020Article
- The Effect of Question Order on Outcomes in the Core Outcome Set for Brief Alcohol Interventions Among Online Help-Seekers: Protocol for a Factorial Randomized Trial.JMIR research protocols · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bayesian approaches to the monitoring of group sequential designs have two main advantages compared with classical group sequential designs: first, they facilitate implementation of interim success and futility criteria that are tailored to the subsequent decision making, and second, they allow inclusion of prior information on the treatment difference and on the control group. A general class of Bayesian group sequential designs is presented, where multiple criteria based on the posterior distribution can be defined to reflect clinically meaningful decision criteria on whether to stop or continue the trial at the interim analyses. To evaluate the frequentist operating characteristics of these designs, both simulation methods and numerical integration methods are proposed, as implemented in the corresponding R package gsbDesign. Normal approximations are used to allow fast calculation of these characteristics for various endpoints. The practical implementation of the approach is illustrated with several clinical trial examples from different phases of drug development, with various endpoints, and informative priors.
Indexed as
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24038922What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.